- Cat. No.
- A11403
MK-8245
MK-8245 is a Liver-Targeted Stearoyl-CoA Desaturase (SCD) Inhibitor. MK-8245 is useful for the Treatment of Diabetes and Dyslipidemia.
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- Cat. No.
- A12318
SC-26196
Selective δ6 desaturase inhibitor (IC50 = 0.2 μM in vitro).
In stock View Details -
- Cat. No.
- A12899
PluriSln 1
stearoyl-CoA desaturase 1 (SCD1) inhibitor. Used to selectively eliminate undifferentiated human pluripotent stem cells (hPSCs) from culture; induces ER stress, attenuates protein synthesis and induces apoptosis in hPSCs. Prevents teratoma formation in immunocompromised mice.
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- Cat. No.
- A13298
A939572
A939572 is a potent, and orally bioavailable stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50 values of
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- Cat. No.
- A15170
MK-8245 Trifluoroacetate
MK-8245 trifluoroacetate is a liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy.
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- Cat. No.
- A16936
CAY10566
CAY10566 is a potent and selective inhibitor of SCD1 that demonstrates IC50 values of 4.5 and 26 nM in mouse and human enzymatic assays, respectively.
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- Cat. No.
- A17149
E6446 dihydrochloride
Synonyms: E 6446
E6446 dihydrochloride is a robust antagonist for TLR7 and TLR9, with potential applications in studying harmful inflammatory responses. Additionally, it acts as a significant inhibitor of SCD1 with a KD of 4.61 μM. This compound can notably suppress adipogenic differentiation and liver lipogenesis via the SCD1-ATF3 pathway. Studies have indicated that E6446 dihydrochloride can enhance liver pathology in mice on a high-fat diet, making it a potential candidate for researching non-alcoholic fatty liver disease (NAFLD).
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- Cat. No.
- A19205
SCD1 inhibitor-1
SCD1 inhibitor-1 is a potent and liver-selective stearoyl-CoA desaturase-1 (SCD1) inhibitor.
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- Cat. No.
- A20150
T-3764518
T-3764518 is a novel and potent stearoyl coenzyme A desaturase (SCD) inhibitor with an IC50 of 4.7 nM.
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- Cat. No.
- A20482
XEN723
XEN723 is a novel and potent thiazolylimidazolidinone inhibitor of Stearoyl-CoA Desaturase (SCD1) with IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively.
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- Cat. No.
- A20766
Aramchol
Synonyms: C20-FABAC
Aramchol, also known as Arachidyl amido cholanoic acid, is a cholesterol solubilizer that prevents gallstone formation in inbred mice. Aramchol reduces liver fat content in patients with nonalcoholic fatty liver disease.
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- Cat. No.
- A20820
GSK1940029
Synonyms: SCD inhibitor 1
GSK1940029 (SCD inhibitor 1) is a stearoyl-coa desaturase (SCD) inhibitor extracted from patent WO/2009060053 A1, compound example 16.
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- Cat. No.
- A20963
MF-438
MF-438 is a potent and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with an EC50 of 2.3 nM for rSCD1.
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- Cat. No.
- A21447
CVT-12012
CVT-12012 is a potent and orally bioavailable stearoyl-coA desaturase (SCD) inhibitor, with IC50s of 38 nM, 6.1 nM for rat microsomal and human HEPG2, respectively.
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- Cat. No.
- A22520
E6446
E6446 is an inhibitor os Toll-like receptor (TLR)7 and 9 signaling.
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- Cat. No.
- A26079
FASN/SCD-IN-1
FASN/SCD-IN-1 is a potent inhibitor of Fatty Acid Synthase (FASN) and Stearoyl-CoA Desaturase (SCD), derived from Silybin. This orally active compound exhibits significant biological activities, including the inhibition of lipid deposition and reduction of FASN and SCD transcription levels. Additionally, FASN/SCD-IN-1 demonstrates antioxidant, anti-inflammatory, and anti-fibrotic properties, with notable hepatoprotective effects in rat models of acute liver injury. Its ability to ameliorate pathological features such as steatosis, inflammation, and fibrosis in mouse models of myeloproliferative steatohepatitis (MASH) makes it a valuable tool for exploring mechanisms underlying MASH-related liver conditions.
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- Cat. No.
- A30192
SSI-4
SSI-4 is a potent stearoyl-CoA desaturase (SCD1) inhibitor with an EC50 of 1.9 nM for mouse SCD1. By blocking the conversion of saturated fatty acids to monounsaturated fatty acids, SSI-4 effectively reduces oleic and palmitoleic acid production. It promotes lipid peroxidation, induces endoplasmic reticulum stress, and activates apoptotic pathways. Additionally, SSI-4 inhibits mTORC1 activity, suppresses B cell proliferation and antibody production, and induces autophagy. This compound is valuable for studies related to cancers such as acute myeloid leukemia and renal cell carcinoma, as well as influenza infections.
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- Cat. No.
- A30605
CVT-11127
Synonyms: GS-456332
CVT-11127 is a potent inhibitor of stearoyl-CoA desaturase (SCD), which plays a crucial role in lipid metabolism. This compound induces apoptosis and causes cell cycle arrest at the G1/S phase, which may impact cellular proliferation. CVT-11127 is primarily utilized in research related to lung cancer, providing valuable insights into therapeutic strategies targeting SCD pathways.
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- Cat. No.
- A32949
TPMP-I-2
TPMP-I-2 is an anticancer agent that targets and induces apoptosis in various cancer cell lines while decreasing the protein levels of stearoyl-CoA desaturase. In preclinical studies, TPMP-I-2 has shown efficacy in prolonging survival in nude rats with simulated micrometastatic cervical cancer and effectively reduces tumor growth in breast cancer models when combined with immunotoxins. This compound serves as a valuable tool for researchers investigating novel cancer therapies.
Out of stock
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- Cat. No.
- A39935
(10E,12Z)-Octadeca-10,12-dienoic acid
Synonyms: trans-10,cis-12 CLA2
(10E,12Z)-Octadeca-10,12-dienoic acid is a potent PPARα activator that plays a critical role in regulating lipid metabolism and adipocyte differentiation. This compound has demonstrated various biological activities, including antioxidant and antitumor effects, alongside the induction of proinflammatory cytokines and chemokines, which may contribute to decreased adipogenesis and insulin resistance. (10E,12Z)-Octadeca-10,12-dienoic acid also influences milk fat synthesis by reducing the expression of lipogenic enzymes and inhibiting fatty acid desaturation. Additionally, it has been shown to modulate lipoprotein lipase activity in cultured adipocytes and alter hepatic stearoyl-CoA desaturase expression in vivo.
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- Cat. No.
- A47998
Elemicin
Elemicin is a potent inhibitor of Stearoyl-CoA Desaturase 1 (SCD1), acting through metabolic activation. This compound exhibits a range of biological activities, including anti-influenza, antimicrobial, antioxidant, and antiviral effects. Its mechanism and diverse applications make Elemicin a valuable reagent for research in metabolic studies and infectious disease treatment. Caution is advised, as Elemicin and its reactive metabolite, 1′-Hydroxyelemicin, may induce hepatotoxicity.
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- Cat. No.
- A54262
SNX7
SNX7 is a selective inhibitor of the Cyclin-Dependent Kinase Inhibitor (CDKI) pathway. This compound plays a crucial role in studying cellular senescence and various CDKI-related diseases. By targeting the CDKI pathway, SNX7 serves as a valuable tool in cancer research and other conditions where cell cycle regulation is disrupted.
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- Cat. No.
- A72247
18:0 Coenzyme A triammonium
18:0 Coenzyme A (triammonium) is a substrate for stearoyl-CoA desaturases (SCDs), enzymes that catalyze the desaturation of saturated fatty acids. This compound plays a crucial role in lipid metabolism and is significant in studies focused on fatty acid synthesis and oxidation. It is widely used in research applications investigating metabolic disorders and adipocyte differentiation.
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- Cat. No.
- A74842
PFM046
PFM046 is a potent antagonist of the liver X receptors (LXRα and LXRβ), demonstrating IC50 values of 2.04 μM and 1.58 μM, respectively. This compound effectively inhibits the expression of stearoyl-CoA desaturase 1 (SCD1) and fatty acid synthase (FASN), while promoting the expression of ATP-binding cassette transporter A1 (ABCA1). PFM046 has shown promising antitumor efficacy in preclinical mouse models, making it a valuable tool for research in cancer therapeutics and lipid metabolism pathways.
Out of stock
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- Cat. No.
- A77848
Sterculic acid
Sterculic acid is a selective inhibitor of stearoyl-CoA desaturase-1 (SCD1), targeting the delta-9 desaturase (Δ9D) activity. It demonstrates significant inhibitory potency with an IC50 value of 0.9 μM. This compound is useful in studies exploring metabolic disorders, lipid metabolism, and the role of SCD1 in various disease states.
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