CYC116 (CYC-116)

Catalog No.: A10248

Aurora Kinase inhibitor

CYC116 (CYC-116)

CYC116 (CYC-116) Chemical Structure

CAS NO. 693228-63-6

Aurora kinase/VEGFR 2 inhibitor CYC116 inhibits Aurora kinases A and B and vascular endothelial growth factor receptor 2 (VEGFR2), resulting in disruption of the cell cycle, rapid cell death, and the inhibition of angiogenesis.

Availability: In stock

Package Price Qty
10 mg

Regular Price: $70.00

Special Price $56.00

50 mg

Regular Price: $200.00

Special Price $160.00

100 mg

Regular Price: $350.00

Special Price $280.00

10mM * 1mL in DMSO
$85.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Details

Aurora kinase/VEGFR 2 inhibitor CYC116 inhibits Aurora kinases A and B and vascular endothelial growth factor receptor 2 (VEGFR2), resulting in disruption of the cell cycle, rapid cell death, and the inhibition of angiogenesis.
Targets
Target Value
AuroraAki: 8nM
AuroraBki: 9nM
VEGFR2ki: 44nM
FLT3ki: 44nM
CDK2/CyclinEki: 0.39μM
CDK9/CyclinTki: 0.48μM
p70S6Kki: 0.54μM
Srcki: 0.82μM
CDK4/CyclinDki: 1.09μM
LCKki: 2.8μM
CDK1/CyclinBki: >10μM
CDK7/CyclinHki: >10μM
Ablki: >10μM
Aktki: >10μM
CaMKIIki: >10μM
CK2ki: >10μM
ERK2ki: >10μM
GSK-3αki: >10μM
GSK-3βki: >10μM
PKAki: >10μM
PKCki: >10μM
SAPK2A(p38α)ki: >10μM
PLK1ki: >10μM
In vitro (25°C) DMSO 24 mg/mL heating (65.13 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.14 mL 135.69 mL 271.37 mL
0.5 mM 5.43 mL 27.14 mL 54.27 mL
1 mM 2.71 mL 13.57 mL 27.14 mL
5 mM 0.54 mL 2.71 mL 5.43 mL

*The above data is based on the productmolecular weight 368.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

Catalog Num A10248
Actions Inhibitor
M. Wt 368.5
Formula C18H20N6OS
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 693228-63-6
Synonyms CYC-116
SMILES CC1=C(SC(=N1)N)C2=NC(=NC=C2)NC3=CC=C(C=C3)N4CCOCC4

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