Cyclosporine

Catalog No.: A15434

Calcineurin inhibitor

Cyclosporine

Cyclosporine Chemical Structure

CAS NO. 79217-60-0

Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation.

Availability: In stock

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100 mg
$120.00
250 mg
$250.00
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Warning WARNING: Attention California Residents: This product can expose you to chemicals including Cyclosporine , which is known to the State of California to cause cancer and birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation.
Targets
calcineurin phosphatase
In vitro (25°C) DMSO Warmed: 85 mg/mL (70.68 mM)
Water Insoluble
Ethanol 85 mg/mL (70.68 mM)
In vivo 2% DMSO+40% PEG 300+2% Tween 80+ddH2O 2 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 8.32 mL 41.58 mL 83.15 mL
0.5 mM 1.66 mL 8.32 mL 16.63 mL
1 mM 0.83 mL 4.16 mL 8.32 mL
5 mM 0.17 mL 0.83 mL 1.66 mL

*The above data is based on the productmolecular weight 1202.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15434
Actions Inhibitor
CAS No. 79217-60-0
Formula C62H111N11O12
M. Wt 1202.61
Solubility DMSO
Purity >98%
SMILES CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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