CZC24832

Catalog No.: A11363

PI3K inhibitor

CZC24832

CZC24832 Chemical Structure

CAS NO. 1159824-67-5

CZC24832 is a selective inhibitor of PI 3-Kinase γ (IC50 = 1.0 μM in a PI 3-Kγ-dependent fMLP-induced neutrophil migration assay).

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5 mg
$80.00
10 mg
$140.00
25 mg
$280.00
50 mg
$480.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Yoshihiro Umezawa, .et al. Molecular mechanisms for enhancement of stromal cell-derived factor 1-induced chemotaxis by platelet endothelial cell adhesion molecule 1 (PECAM-1), J Biol Chem, 2017, Dec 1; 292(48): 19639-19655 PMID: 28974577

Biological Activity

CZC24832 is a selective inhibitor of PI 3-Kinase γ (IC50 = 1.0 μM in a PI 3-Kγ-dependent fMLP-induced neutrophil migration assay).
Targets
PI3Kγ PI3Kβ PI3Kδ
27 nM1.1 μM8.2 μM
In vitro (25°C) DMSO Warmed: 5 mg/mL (13.72 mM)
Water Insoluble
Ethanol Insoluble
In vivo 0.5% CMC 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.44 mL 137.21 mL 274.42 mL
0.5 mM 5.49 mL 27.44 mL 54.88 mL
1 mM 2.74 mL 13.72 mL 27.44 mL
5 mM 0.55 mL 2.74 mL 5.49 mL

*The above data is based on the productmolecular weight 364.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11363
Actions Inhibitor
CAS No. 1159824-67-5
Formula C15H17FN6O2S
M. Wt 364.4
Solubility DMSO
Purity >98%
Synonyms CZC 24832, CZC-24832
SMILES CC(C)(C)NS(=O)(=O)C1=CN=CC(=C1)C2=CN3C(=NC(=N3)N)C(=C2)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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