CZL-077 is a selective and potent inhibitor of the bromodomains of p300 and CBP, with IC50 values of 0.034 μM and 0.052 μM, respectively. It demonstrates high specificity for p300/CBP over BET proteins, making it a valuable tool in the study of epigenetic regulation. CZL-077 effectively inhibits the growth of multiple myeloma and prostate cancer cell lines, with IC50 values of 0.024 μM in OPM-2 and 5.6 μM in 22RV1 cells. Additionally, it exhibits significant antitumor activity in xenograft mouse models, supporting its potential use in cancer research.
CZL-077 is a selective and potent inhibitor of the bromodomains of p300 and CBP, with IC50 values of 0.034 μM and 0.052 μM, respectively. It demonstrates high specificity for p300/CBP over BET proteins, making it a valuable tool in the study of epigenetic regulation. CZL-077 effectively inhibits the growth of multiple myeloma and prostate cancer cell lines, with IC50 values of 0.024 μM in OPM-2 and 5.6 μM in 22RV1 cells. Additionally, it exhibits significant antitumor activity in xenograft mouse models, supporting its potential use in cancer research.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
