D-Arabinopyranose is a rare aldo-pentose that serves as a precursor to D-arabinose in its open-chain form. This compound exhibits significant biological activity, including antidepressant effects and growth inhibition in Caenorhabditis elegans with an IC50 of 7.5 mM. D-Arabinose penetrates the blood-brain barrier, specifically modulating the metabolism of D-ribose and D-fructose, while also demonstrating antibacterial properties by inhibiting biofilm synthesis. Additionally, it activates the ACSS2-PPARγ/TFEB-CRTC1 axis via the lysosomal AXIN-LKB1-AMPK pathway, leading to antidepressant-like outcomes.
D-Arabinopyranose is a rare aldo-pentose that serves as a precursor to D-arabinose in its open-chain form. This compound exhibits significant biological activity, including antidepressant effects and growth inhibition in Caenorhabditis elegans with an IC50 of 7.5 mM. D-Arabinose penetrates the blood-brain barrier, specifically modulating the metabolism of D-ribose and D-fructose, while also demonstrating antibacterial properties by inhibiting biofilm synthesis. Additionally, it activates the ACSS2-PPARγ/TFEB-CRTC1 axis via the lysosomal AXIN-LKB1-AMPK pathway, leading to antidepressant-like outcomes.
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