D-threo-PDMP hydrochloride is a potent inhibitor of glucoceramide synthase (GCS), effectively reducing glycosphingolipids such as GM3 and GD3 on the cell surface. This compound impairs glycosylation processes, leading to reduced axonal growth and branching, as well as decreased adhesion of B16 melanoma cells, effectively mimicking the effects of hyperglycemia and TGF-β1. Additionally, D-threo-PDMP hydrochloride protects hepatocytes from TNF-α-induced apoptosis by inhibiting GD3 synthesis. This reagent is valuable for research into diseases associated with glycosphingolipid metabolism.
D-threo-PDMP hydrochloride is a potent inhibitor of glucoceramide synthase (GCS), effectively reducing glycosphingolipids such as GM3 and GD3 on the cell surface. This compound impairs glycosylation processes, leading to reduced axonal growth and branching, as well as decreased adhesion of B16 melanoma cells, effectively mimicking the effects of hyperglycemia and TGF-β1. Additionally, D-threo-PDMP hydrochloride protects hepatocytes from TNF-α-induced apoptosis by inhibiting GD3 synthesis. This reagent is valuable for research into diseases associated with glycosphingolipid metabolism.
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