Dabrafenib (GSK2118436A)

Dabrafenib is a potent and selective inhibitor of B-RAF protein kinase carrying V600E mutation, currently in clinical trial.
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Dabrafenib 5mg
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Dabrafenib 25mg
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Dabrafenib 50mg
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Dabrafenib 100mg
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Dabrafenib (GSK2118436A) 10mM * 1mL in DMSO
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Adooq Products cited in reputable paper
Adooq's Dabrafenib (GSK2118436A) has been cited by 7 publications
  • Ali Talebi, .et al. , J Exp Clin Cancer Res, 2023, Apr 19;42(1):92 PMID: 37072838
  • Yuki Shimizu, .et al. , Cancer Lett, 2022, Sep 1;543 PMID: 35724767
  • Aya Hasan Alshammari, .et al. , Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812
  • Chenyang He, .et al. , Clinical and Translational Biophotonics, 2020, TTh3B.2
  • Hirosumi Tamura, .et al. , Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168
  • Brittany M. Duggan, .et al. , Sci Rep, 2017, 7: 1578 PMID: 28484277
  • Fujita KI, .et al. , J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
  • Biological Activity
    Discription Dabrafenib is a potent and selective inhibitor of B-RAF protein kinase carrying V600E mutation, currently in clinical trial.
    Target Value
    Product Information
    Catalog Num A11381
    Formula C23H20F3N5O2S2
    Molecular Weight 519.6
    CAS Number 1195765-45-7
    SMILES CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F
    Synonyms GSK2118436A

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    In vitro (25°C) DMSO 28 mg/mL (53.89 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 2% DMSO+45% PEG 300+2% Tween 80+ddH2O 4 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 19.25 mL 96.23 mL 192.46 mL
    0.5 mM 3.85 mL 19.25 mL 38.49 mL
    1 mM 1.92 mL 9.62 mL 19.25 mL
    5 mM 0.38 mL 1.92 mL 3.85 mL
    Useful Calculator

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    Calculate the dilution required to prepare a stock solution.
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