Dabrafenib (GSK2118436A)

Dabrafenib is a potent and selective inhibitor of B-RAF protein kinase carrying V600E mutation, currently in clinical trial.
Grouped product items
Size Price Stock Qty
5mg
$35.00
In stock
10mg
$50.00
In stock
25mg
$65.00
In stock
50mg
$80.00
In stock
100mg
$110.00
In stock
200mg
$150.00
In stock
500mg
$320.00
In stock
1g
$620.00
In stock
10mM * 1mL in DMSO
$40.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500

Important Notice: For research use only. We do not sell to patients.

Loading distributor info...

Adooq Products cited in reputable paper
Adooq's Dabrafenib (GSK2118436A) has been cited by 8 publications
  • Rana Can Baygin, .et al. , Sci Rep, 2024, Jan 2;14(1):286 PMID: 38167959
  • Ali Talebi, .et al. , J Exp Clin Cancer Res, 2023, Apr 19;42(1):92 PMID: 37072838
  • Yuki Shimizu, .et al. , Cancer Lett, 2022, Sep 1;543 PMID: 35724767
  • Aya Hasan Alshammari, .et al. , Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812
  • Chenyang He, .et al. , Clinical and Translational Biophotonics, 2020, TTh3B.2
  • Hirosumi Tamura, .et al. , Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168
  • Brittany M. Duggan, .et al. , Sci Rep, 2017, 7: 1578 PMID: 28484277
  • Fujita KI, .et al. , J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
  • Biological Activity
    Discription Dabrafenib is a potent and selective inhibitor of B-RAF protein kinase carrying V600E mutation, currently in clinical trial.
    Targets
    Target Value
    Cell Research
    Cell Line Type Value Description References
    Product Information
    Catalog Num A11381
    Formula C23H20F3N5O2S2
    Molecular Weight 519.6
    CAS Number 1195765-45-7
    SMILES CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F
    Synonyms GSK2118436A
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 28 mg/mL (53.89 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 2% DMSO+45% PEG 300+2% Tween 80+ddH2O 4 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 19.25 mL 96.23 mL 192.46 mL
    0.5 mM 3.85 mL 19.25 mL 38.49 mL
    1 mM 1.92 mL 9.62 mL 19.25 mL
    5 mM 0.38 mL 1.92 mL 3.85 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

    • Mass

      Concentration

      Volume

      Molecular Weight

    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

    • C1

      V1

      C2

      V2

    • Calculator Reset
    Keywords: buy Dabrafenib (GSK2118436A) | Dabrafenib (GSK2118436A) Supplier | purchase Dabrafenib (GSK2118436A) | Dabrafenib (GSK2118436A) cost | Dabrafenib (GSK2118436A) manufacturer | order Dabrafenib (GSK2118436A) | Dabrafenib (GSK2118436A) distributor | buy 1195765-45-7 | 1195765-45-7 Supplier | purchase 1195765-45-7 | 1195765-45-7 cost | 1195765-45-7 manufacturer | order 1195765-45-7 | 1195765-45-7 distributor