Dabrafenib (GSK2118436A)

Catalog No.: A11381

Raf inhibitor

Dabrafenib (GSK2118436A) Chemical Structure

CAS NO. 1195765-45-7

Dabrafenib is a potent and selective inhibitor of B-RAF protein kinase carrying V600E mutation, currently in clinical trial.

Availability: In stock

Package Price Qty
5 mg
$50.00
25 mg
$70.00
50 mg
$90.00
100 mg
$125.00
10mM * 1mL in DMSO
$50.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Dabrafenib is a potent and selective inhibitor of B-RAF protein kinase carrying V600E mutation, currently in clinical trial.
Targets
B-Raf (V600E) (Cell-free assay) B-Raf (Cell-free assay) C-Raf (Cell-free assay)
0.8 nM3.2 nM5.0 nM
In vitro (25°C) DMSO 30 mg/mL (57.74 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 8 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.25 mL 96.23 mL 192.46 mL
0.5 mM 3.85 mL 19.25 mL 38.49 mL
1 mM 1.92 mL 9.62 mL 19.25 mL
5 mM 0.38 mL 1.92 mL 3.85 mL

*The above data is based on the productmolecular weight 519.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11381
Actions Inhibitor
M. Wt 519.6
Formula C23H20F3N5O2S2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1195765-45-7
Synonyms GSK2118436A
SMILES CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F

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