Dabrafenib (GSK2118436A)

Catalog No.: A11381

Raf inhibitor

Dabrafenib (GSK2118436A)

Dabrafenib (GSK2118436A) Chemical Structure

CAS NO. 1195765-45-7

Dabrafenib is a potent and selective inhibitor of B-RAF protein kinase carrying V600E mutation, currently in clinical trial.

Availability: In stock

Package Price Qty
5 mg
$50.00
25 mg
$70.00
50 mg
$90.00
100 mg
$125.00
10mM * 1mL in DMSO
$50.00
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  • Chenyang He, .et al. Detection of Dabrafenib using Optical Fibre Long Period Grating Sensor Modified with Surface Imprinted Polymers for Dose Detection and Prevention of Cancer Resistance, Clinical and Translational Biophotonics, 2020, TTh3B.2
  • Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168
  • Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
  • Brittany M. Duggan, .et al. Tyrosine kinase inhibitors of Ripk2 attenuate bacterial cell wall-mediated lipolysis, inflammation and dysglycemia, Sci Rep, 2017, 7: 1578 PMID: 28484277

Biological Activity

Dabrafenib is a potent and selective inhibitor of B-RAF protein kinase carrying V600E mutation, currently in clinical trial.
Targets
B-Raf (V600E) (Cell-free assay) B-Raf (Cell-free assay) C-Raf (Cell-free assay)
0.8 nM3.2 nM5.0 nM
In vitro (25°C) DMSO 30 mg/mL (57.74 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 8 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.25 mL 96.23 mL 192.46 mL
0.5 mM 3.85 mL 19.25 mL 38.49 mL
1 mM 1.92 mL 9.62 mL 19.25 mL
5 mM 0.38 mL 1.92 mL 3.85 mL

*The above data is based on the productmolecular weight 519.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11381
Actions Inhibitor
M. Wt 519.6
Formula C23H20F3N5O2S2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1195765-45-7
Synonyms GSK2118436A
SMILES CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F

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