Dabrafenib (GSK2118436A)
Important Notice: For research use only. We do not sell to patients.
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Important Notice: For research use only. We do not sell to patients.
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Discription | Dabrafenib is a potent and selective inhibitor of B-RAF protein kinase carrying V600E mutation, currently in clinical trial. | ||
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Targets |
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Catalog Num | A11381 |
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Formula | C23H20F3N5O2S2 |
Molecular Weight | 519.6 |
CAS Number | 1195765-45-7 |
SMILES | CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F |
Synonyms | GSK2118436A |
Storage | Store lyophilized at -20ºC, keep desiccated. |
In vitro (25°C) | DMSO | 28 mg/mL (53.89 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 2% DMSO+45% PEG 300+2% Tween 80+ddH2O | 4 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
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0.1 mM | 19.25 mL | 96.23 mL | 192.46 mL |
0.5 mM | 3.85 mL | 19.25 mL | 38.49 mL |
1 mM | 1.92 mL | 9.62 mL | 19.25 mL |
5 mM | 0.38 mL | 1.92 mL | 3.85 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2