Dagrocorat hydrochloride is a selective partial agonist of the glucocorticoid receptor, exhibiting high affinity and oral bioavailability. This compound functions as a time-dependent reversible inhibitor of CYP3A and CYP2D6, demonstrating inhibitory activity with IC50 values of 1.3 μM and Ki of 0.57 μM, respectively, in human liver microsomes. Dagrocorat hydrochloride is primarily utilized in research related to rheumatoid arthritis, facilitating studies on glucocorticoid signaling pathways and related therapeutic applications.
Dagrocorat hydrochloride is a selective partial agonist of the glucocorticoid receptor, exhibiting high affinity and oral bioavailability. This compound functions as a time-dependent reversible inhibitor of CYP3A and CYP2D6, demonstrating inhibitory activity with IC50 values of 1.3 μM and Ki of 0.57 μM, respectively, in human liver microsomes. Dagrocorat hydrochloride is primarily utilized in research related to rheumatoid arthritis, facilitating studies on glucocorticoid signaling pathways and related therapeutic applications.
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