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Publications citing Adooq Products
Dapagliflozin (BMS512148) Citations (1)
- Angelopoulou A,et al. Magnetic Nanoparticles for the Delivery of Dapagliflozin to Hypoxic Tumors: Physicochemical Characterization and Cell Studies, AAPS PharmSciTech, 2018, Feb;19(2):621-633 8924948
Chemical Information
| Catalog Num | A10285 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 408.9 |
| Formula | C21H25ClO6 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 461432-26-8 |
| Synonyms | BMS512148, BMS-512148 |
| SMILES code | CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)[[email protected]]3[[email protected]@H]([[email protected]]([[email protected]@H]([[email protected]](O3)CO)O)O)O)Cl |
| Chemical Name | (2S,3R,4R,5S,6R)-2-[4-chloro-3-(4-ethoxybenzyl)phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol |
Description |
Dapagliflozin inhibits subtype 2 of the sodium-glucose transport proteins (SGLT2), which is responsible for at least 90% of the glucose reabsorption in the kidney. | |||||
| Solubility (25°C) * | In vitro | DMSO | 82 mg/mL (200.55 mM) |
|---|---|---|---|
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 17 mg/mL (41.57 mM) | ||
| In vivo | 30% PEG400/0.5% Tween80/5% propylene glycol | 30 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.46 mL | 122.28 mL | 244.56mL |
| 0.5 mM | 4.89 mL | 24.46 mL | 48.91 mL |
| 1 mM | 2.45 mL | 12.23 mL | 24.46 mL |
| 5 mM | 0.49 mL | 2.45 mL | 4.89 mL |
*The above data is based on the productmolecular weight 408.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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