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Dasatinib (BMS-354825)


Abl-Src inhibitor

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Catalog No. A10290

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Dasatinib (BMS-354825) 25mg A10290-25

Regular Price: $60.00

Special Price: $54.00

Dasatinib (BMS-354825) 50mg A10290-50

Regular Price: $90.00

Special Price: $81.00

Dasatinib (BMS-354825) 100mg A10290-100

Regular Price: $140.00

Special Price: $126.00

Dasatinib (BMS-354825) 200mg A10290-200

Regular Price: $220.00

Special Price: $198.00

Dasatinib (BMS-354825) 10mM * 1mL in DMSO A10290-10mM-D

Regular Price: $71.00

Special Price: $63.90

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Dasatinib (BMS-354825) is an oral multi- BCR/ABL and Src family tyrosine kinase inhibitor. The main targets of dasatinib, are BCR/ABL, Src, c-Kit, ephrin receptors, and several other tyrosine kinases, but not erbB kinases such as EGFR or Her2.

Dasatinib (BMS-354825)

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Publications citing Adooq Products
Dasatinib (BMS-354825) Citations (6)
  • Li Li, .et al. Evidence for activated Lck protein tyrosine kinase as the driver of proliferation in acute myeloid leukemia cell, CTV-1, Leukemia Res, 2019, 78:12-20 PMID: 30660961
  • Sano T, .et al. Gliding Basal Cell Migration of the Urothelium during Wound Healing, Am J Pathol, 2018, Nov;188(11):2564-2573 PMID: 30121259
  • Ines Peschel, .et al. FLT3 and FLT3-ITD phosphorylate and inactivate the cyclin-dependent kinase inhibitor p27Kip1 in acute myeloid leukemia, Haematologica, 2017, Aug; 102(8): 1378-1389 PMID: 28522571
  • Brittany M. Duggan, .et al. Tyrosine kinase inhibitors of Ripk2 attenuate bacterial cell wall-mediated lipolysis, inflammation and dysglycemia, Sci Rep, 2017, 7: 1578 PMID: 28484277
  • John D. Leonard, .et al. Identification of natural regulatory T cell epitopes reveals convergence on a dominant autoantigen, Immunity, 2017, Jul 18; 47(1): 107-117.e8. PMID: 28709804
  • Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358

Chemical Information

Catalog Num A10290
Actions Inhibitor
M. Wt 488.0
Formula C22H26ClN7O2S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 302962-49-8
Synonyms Sprycel

Biological Activity

Dasatinib (BMS-354825) is an oral multi- BCR/ABL and Src family tyrosine kinase inhibitor. The main targets of dasatinib, are BCR/ABL, Src, c-Kit, ephrin receptors, and several other tyrosine kinases, but not erbB kinases such as EGFR or Her2.
Abl (Cell-free assay) Src (Cell-free assay) c-Kit (D816V) (Cell-free assay) c-Kit (wt) (Cell-free assay)
0.6 nM0.8 nM37 nM79 nM


Solubility (25°C) * In vitro DMSO 98 mg/mL (200.81 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.49 mL 102.46 mL 204.92mL
0.5 mM 4.1 mL 20.49 mL 40.98 mL
1 mM 2.05 mL 10.25 mL 20.49 mL
5 mM 0.41 mL 2.05 mL 4.1 mL

*The above data is based on the productmolecular weight 488.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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