Dasatinib (BMS-354825)

Catalog No.: A10290

Abl-Src inhibitor

Dasatinib (BMS-354825) Chemical Structure

CAS NO. 302962-49-8

Dasatinib (BMS-354825) is an oral multi- BCR/ABL and Src family tyrosine kinase inhibitor. The main targets of dasatinib, are BCR/ABL, Src, c-Kit, ephrin receptors, and several other tyrosine kinases, but not erbB kinases such as EGFR or Her2.

Availability: In stock

Package Price Qty
25 mg
$60.00
50 mg
$90.00
100 mg
$55.00
200 mg
$70.00
10mM * 1mL in DMSO
$60.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Dasatinib (BMS-354825) is an oral multi- BCR/ABL and Src family tyrosine kinase inhibitor. The main targets of dasatinib, are BCR/ABL, Src, c-Kit, ephrin receptors, and several other tyrosine kinases, but not erbB kinases such as EGFR or Her2.
Targets
Abl (Cell-free assay) Src (Cell-free assay) c-Kit (D816V) (Cell-free assay) c-Kit (wt) (Cell-free assay)
0.6 nM0.8 nM37 nM79 nM
In vitro (25°C) DMSO 98 mg/mL (200.81 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.49 mL 102.46 mL 204.92 mL
0.5 mM 4.1 mL 20.49 mL 40.98 mL
1 mM 2.05 mL 10.25 mL 20.49 mL
5 mM 0.41 mL 2.05 mL 4.1 mL

*The above data is based on the productmolecular weight 488.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10290
Actions Inhibitor
M. Wt 488.0
Formula C22H26ClN7O2S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 302962-49-8
Synonyms Sprycel
SMILES CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=NC(=NC(=C3)N4CCN(CC4)CCO)C

Product Tags

Product Tags

Other people marked this product with these tags:

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
Keywords:buy Dasatinib (BMS-354825) | Dasatinib (BMS-354825) Supplier | purchase Dasatinib (BMS-354825) | Dasatinib (BMS-354825) cost | Dasatinib (BMS-354825) manufacturer | order Dasatinib (BMS-354825) | Dasatinib (BMS-354825) distributor | buy 302962-49-8| 302962-49-8 Supplier | purchase 302962-49-8 | 302962-49-8 cost | 302962-49-8 manufacturer | order 302962-49-8 | 302962-49-8 distributor
Rewards