Fig. 1 · Structure
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DBPR110
Cat. No.
A73171
CAS
1310694-75-7
Endogenous Metabolite
DBPR110 is a potent inhibitor of nonstructural protein 5A (NS5A), specifically targeting hepatitis C virus (HCV) replication. It demonstrates significant antiviral activity with an EC50 of 3.9 ± 0.9 pM against HCV1b replicon reporter expression, and a selectivity index exceeding 12,800,000. Additionally, DBPR110 reduces HCV2a replicon activity with an EC50 of 228.8 pM and a selectivity index of over 173,130. This compound exhibits synergistic effects when used in combination with interferon alpha (IFN-α) and other antiviral agents, suggesting its potential as a viable small molecule therapeutic for HCV treatment.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1310694-75-7 |
| Applications | Endogenous Metabolite |
| Formula | C50H48N6O4S2 |
| Molecular Weight | 861.08 |
| SMILES | O=C(C1CC1)N[C@H](C2=CC=CC=C2)C(N3[C@H](C4=NC=C(C5=CC=C(C6=CC=C(C7=CN=C([C@H]8N(CCC8)C([C@@H](C9=CC=CC=C9)NC(C%10CC%10)=O)=O)S7)C=C6)C=C5)S4)CCC3)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.