DCG066 is a selective inhibitor of the lysine methyltransferase G9a, effectively binding to G9a and obstructing its methyltransferase activity in vitro. This compound has been shown to decrease di-methylation levels of histone H3 at lysine 9 (H3K9Me2), leading to inhibition of cell proliferation and induction of apoptosis. Additionally, DCG066 exhibits low cytotoxicity in leukemia cell lines characterized by elevated G9a expression, such as K562, making it a valuable tool for studying the role of G9a in oncogenesis and potential therapeutic applications.
DCG066 is a selective inhibitor of the lysine methyltransferase G9a, effectively binding to G9a and obstructing its methyltransferase activity in vitro. This compound has been shown to decrease di-methylation levels of histone H3 at lysine 9 (H3K9Me2), leading to inhibition of cell proliferation and induction of apoptosis. Additionally, DCG066 exhibits low cytotoxicity in leukemia cell lines characterized by elevated G9a expression, such as K562, making it a valuable tool for studying the role of G9a in oncogenesis and potential therapeutic applications.
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