DDC-01-163 is an allosteric PROTAC degrader that targets the epidermal growth factor receptor (EGFR) through the ubiquitin-proteasome system. It demonstrates selective inhibition of L858R/T790M mutant Ba/F3 cell proliferation and is effective against resistant variants, including L/T/C797S and L/T/L718Q EGFR mutations. DDC-01-163 exhibits enhanced anti-proliferative effects in combination with the ATP-site EGFR inhibitor Osimertinib, making it a valuable tool for studying non-small cell lung cancer.
DDC-01-163 is an allosteric PROTAC degrader that targets the epidermal growth factor receptor (EGFR) through the ubiquitin-proteasome system. It demonstrates selective inhibition of L858R/T790M mutant Ba/F3 cell proliferation and is effective against resistant variants, including L/T/C797S and L/T/L718Q EGFR mutations. DDC-01-163 exhibits enhanced anti-proliferative effects in combination with the ATP-site EGFR inhibitor Osimertinib, making it a valuable tool for studying non-small cell lung cancer.
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