Deacetylsclerotiorin is an endogenous metabolite derived from chloramphenicol, sourced from the fungus Bartalinia robillardoides strain LF550. This compound demonstrates significant antifungal activity, effectively inhibiting Candida albicans (IC50=24 μM), Trichophyton rubrum (IC50=2.83 μM), and Septoria tritici (IC50=7.45 μM). Furthermore, Deacetylsclerotiorin inhibits phosphodiesterase 4 (PDE4) with an IC50 of 2.8 μM, highlighting its potential utility in enzyme inhibition studies and antifungal research applications.
Deacetylsclerotiorin is an endogenous metabolite derived from chloramphenicol, sourced from the fungus Bartalinia robillardoides strain LF550. This compound demonstrates significant antifungal activity, effectively inhibiting Candida albicans (IC50=24 μM), Trichophyton rubrum (IC50=2.83 μM), and Septoria tritici (IC50=7.45 μM). Furthermore, Deacetylsclerotiorin inhibits phosphodiesterase 4 (PDE4) with an IC50 of 2.8 μM, highlighting its potential utility in enzyme inhibition studies and antifungal research applications.
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