Catalog No.: A14012

JAK3 inhibitor


Decernotinib Chemical Structure

CAS NO. 944842-54-0

Decernotinib is an oral, selective Janus kinase 3 (JAK3) inhibitor being developed by Vertex.

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2 mg
5 mg
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Biological Activity

Decernotinib is an oral, selective Janus kinase 3 (JAK3) inhibitor being developed by Vertex.
2.5 nM(Ki)11 nM11 nM(Ki)13 nM(Ki)13 nM(Ki)
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.49 mL 127.43 mL 254.85 mL
0.5 mM 5.1 mL 25.49 mL 50.97 mL
1 mM 2.55 mL 12.74 mL 25.49 mL
5 mM 0.51 mL 2.55 mL 5.1 mL

*The above data is based on the productmolecular weight 392.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14012
Actions Inhibitor
M. Wt 392.38
Formula C18H19F3N6O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 944842-54-0
Synonyms VX-509, VX509, VX 509, VRT-831509, VRT831509, VRT 831509
SMILES CC[[email protected]](C)(C(=O)NCC(F)(F)F)NC1=NC(=NC=C1)C2=CNC3=C2C=CC=N3

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