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JAK3 inhibitor

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Catalog No. A14012

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Decernotinib 2mg A14012-2
Decernotinib 5mg A14012-5

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Decernotinib is an oral, selective Janus kinase 3 (JAK3) inhibitor being developed by Vertex.


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Chemical Information

Catalog Num A14012
Actions Inhibitor
M. Wt 392.38
Formula C18H19F3N6O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 944842-54-0
Synonyms VX-509, VX509, VX 509, VRT-831509, VRT831509, VRT 831509
SMILES CC[[email protected]](C)(C(=O)NCC(F)(F)F)NC1=NC(=NC=C1)C2=CNC3=C2C=CC=N3

Biological Activity

Decernotinib is an oral, selective Janus kinase 3 (JAK3) inhibitor being developed by Vertex.
2.5 nM(Ki)11 nM11 nM(Ki)13 nM(Ki)13 nM(Ki)

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.49 mL 127.43 mL 254.85mL
0.5 mM 5.1 mL 25.49 mL 50.97 mL
1 mM 2.55 mL 12.74 mL 25.49 mL
5 mM 0.51 mL 2.55 mL 5.1 mL

*The above data is based on the productmolecular weight 392.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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