Delta3,5-cholestadien-7-one is an oxysterol that functions as a negative allosteric modulator of GABAA receptors. It effectively reduces GABA-induced currents in HEK cells expressing GABAA receptor subunits α1β1γ2 and α4β3γ2, with IC50 values of 1.5 µM and 1 µM, respectively. Additionally, Delta3,5-cholestadien-7-one attenuates GABA-induced depolarization in both peptidergic and non-peptidergic nociceptors, C-LTMRs, and cold thermosensors in isolated mouse dorsal root ganglion neurons, making it valuable for research on pain perception and sensory signaling.
Delta3,5-cholestadien-7-one is an oxysterol that functions as a negative allosteric modulator of GABAA receptors. It effectively reduces GABA-induced currents in HEK cells expressing GABAA receptor subunits α1β1γ2 and α4β3γ2, with IC50 values of 1.5 µM and 1 µM, respectively. Additionally, Delta3,5-cholestadien-7-one attenuates GABA-induced depolarization in both peptidergic and non-peptidergic nociceptors, C-LTMRs, and cold thermosensors in isolated mouse dorsal root ganglion neurons, making it valuable for research on pain perception and sensory signaling.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
