Dendrotoxin K

Catalog No.: A68182
Kv1.1 Channel Blocker
Dendrotoxin K is a selective blocker of the Kv1.1 potassium channel, influencing neuronal excitability. It modulates glutamate release in CA3 neurons in a time-dependent manner by altering the presynaptic spike waveform, making it a valuable tool for studying synaptic transmission and neuronal signaling. This compound is useful for investigations into neuronal circuit dynamics and pathophysiological conditions involving ion channel function.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionDendrotoxin K is a selective blocker of the Kv1.1 potassium channel, influencing neuronal excitability. It modulates glutamate release in CA3 neurons in a time-dependent manner by altering the presynaptic spike waveform, making it a valuable tool for studying synaptic transmission and neuronal signaling. This compound is useful for investigations into neuronal circuit dynamics and pathophysiological conditions involving ion channel function.
Product Information
Catalog NumA68182
FormulaC294H462N84O75S6
Molecular Weight6559.66
CAS Number119128-61-9
SequenceAla-Ala-Lys-Tyr-Cys-Lys-Leu-Pro-Leu-Arg-Ile-Gly-Pro-Cys-Lys-Arg-Lys-Ile-Pro-Ser-Phe-Tyr-Tyr-Lys-Trp-Lys-Ala-Lys-Gln-Cys-Leu-Pro-Phe-Asp-Tyr-Ser-Gly-Cys-Gly-Gly-Asn-Ala-Asn-Arg-Phe-Lys-Thr-Ile-Glu-Glu-Cys-Arg-Arg-Thr-Cys-Val-Gly (Disulfide bridge:Cys5-Cys55,Cys14-Cys38,Cys30-Cys51)
Sequence shorteningAAKYCKLPLRIGPCKRKIPSFYYKWKAKQCLPFDYSGCGGNANRFKTIEECRRTCVG (Disulfide bridge:Cys5-Cys55,Cys14-Cys38,Cys30-Cys51)
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