Fig. 1 · Structure
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Dersimelagon
MC1R Agonist
Dersimelagon is a selective agonist of the melanocortin 1 receptor (MC1R) with demonstrated efficacy in human (EC50 of 8.16 nM), cynomolgus monkey (3.91 nM), mouse (1.14 nM), and rat (0.251 nM) models. It exhibits strong binding affinity for hMC1R and hMC4R, with Ki values of 2.26 nM and 32.9 nM, respectively. This compound is primarily utilized in research focused on skin pigmentation and the modulation of melanin synthesis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 1835256-48-8 |
| Applications | MC1R Agonist |
| Formula | C36H45F4N3O5 |
| Molecular Weight | 675.75 |
| Synonyms | MT-7117 |
| SMILES | O=C(N1C[C@H](C2=C(N3CCC(C(O)=O)CC3)C=C(C(F)(F)F)C=C2)[C@@H](COC)C1)[C@]4([C@H](C5=CC=C(OC)C=C5)CN(C6CCCC6)C4)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.