DHFR-IN-1 is a selective inhibitor of dihydrofolate reductase (DHFR) with an IC50 of 40.71 nM. This compound demonstrates significant antibacterial activity against both gram-positive and gram-negative bacteria, as well as moderate antifungal properties. Additionally, DHFR-IN-1 exhibits a strong synergistic effect when combined with Levofloxacin, characterized by a fractional inhibitory concentration index (FIC) value of 0.249, making it a valuable candidate for further research in antimicrobial applications.
DHFR-IN-1 is a selective inhibitor of dihydrofolate reductase (DHFR) with an IC50 of 40.71 nM. This compound demonstrates significant antibacterial activity against both gram-positive and gram-negative bacteria, as well as moderate antifungal properties. Additionally, DHFR-IN-1 exhibits a strong synergistic effect when combined with Levofloxacin, characterized by a fractional inhibitory concentration index (FIC) value of 0.249, making it a valuable candidate for further research in antimicrobial applications.
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