Dibenzothiophene-d8 is a deuterium-labeled analogue of dibenzothiophene, serving as a stable isotope for research applications. This compound acts as a noncompetitive inhibitor of cytochrome P450 1A (CYP1A), demonstrating an inhibition of CYP1A-mediated EROD activity with a Km value of 0.592 μM. Additionally, dibenzothiophene-d8 interacts with the aryl hydrocarbon receptor (AHR) pathway and has been shown to enhance the embryotoxic effects of β-naphthoflavone. Its unique properties make it valuable for investigating the mechanisms of developmental toxicity in various organisms.
Dibenzothiophene-d8 is a deuterium-labeled analogue of dibenzothiophene, serving as a stable isotope for research applications. This compound acts as a noncompetitive inhibitor of cytochrome P450 1A (CYP1A), demonstrating an inhibition of CYP1A-mediated EROD activity with a Km value of 0.592 μM. Additionally, dibenzothiophene-d8 interacts with the aryl hydrocarbon receptor (AHR) pathway and has been shown to enhance the embryotoxic effects of β-naphthoflavone. Its unique properties make it valuable for investigating the mechanisms of developmental toxicity in various organisms.
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