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Dinaciclib (SCH 727965)


CDK Inhibitor

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Catalog No. A11129

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Dinaciclib 5mg A11129-5

Regular Price: $70.00

Special Price: $63.00

Dinaciclib 10mg A11129-10

Regular Price: $120.00

Special Price: $108.00

Dinaciclib 25mg A11129-25

Regular Price: $240.00

Special Price: $216.00

Dinaciclib 50mg A11129-50

Regular Price: $380.00

Special Price: $342.00

Dinaciclib (SCH 727965) 10mM * 1mL in DMSO A11129-10mM-D

Regular Price: $80.00

Special Price: $72.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Dinaciclib (SCH 727965) is a potent and selective cyclin-dependent kinase (CDK) inhibitor, selectively inhibiting CDK1, CDK2, CDK5 and CDK9 with IC50 values of 3, 1, 1 and 4 nM respectively.

Dinaciclib (SCH 727965)

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Publications citing Adooq Products
Dinaciclib (SCH 727965) Citations (1)
  • Washio I, .et al. Impact of Breast Cancer Resistance Protein Expression on the In Vitro Efficacy of Anticancer Drugs in Pancreatic Cancer Cell Lines, Drug Metab Dispos, 2018, Mar;46(3):214-222 PMID: 29246888

Chemical Information

Catalog Num A11129
Actions Inhibitor
M. Wt 396.5
Formula C21H28N6O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 779353-01-4
Synonyms SCH727965, SCH-727965
SMILES CCC1=C2N=C(C=C(N2N=C1)NCC3=C[N+](=CC=C3)[O-])N4CCCC[[email protected]]4CCO

Biological Activity

Dinaciclib (SCH 727965) is a potent and selective cyclin-dependent kinase (CDK) inhibitor, selectively inhibiting CDK1, CDK2, CDK5 and CDK9 with IC50 values of 3, 1, 1 and 4 nM respectively.
CDK2 (Cell-free assay) CDK5 (Cell-free assay) CDK1 (Cell-free assay) CDK9 (Cell-free assay)
1 nM1 nM3 nM4 nM


Solubility (25°C) * In vitro DMSO 26 mg/mL heating (65.57 mM)
Water <1 mg/mL (<1 mM)
Ethanol 8 mg/mL heating (20.17 mM)
In vivo 15% Captisol 6 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.22 mL 126.1 mL 252.21mL
0.5 mM 5.04 mL 25.22 mL 50.44 mL
1 mM 2.52 mL 12.61 mL 25.22 mL
5 mM 0.5 mL 2.52 mL 5.04 mL

*The above data is based on the productmolecular weight 396.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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