Dinaciclib (SCH 727965)

Catalog No.: A11129

CDK Inhibitor

Dinaciclib (SCH 727965)

Dinaciclib (SCH 727965) Chemical Structure

CAS NO. 779353-01-4

Dinaciclib (SCH 727965) is a potent and selective cyclin-dependent kinase (CDK) inhibitor, selectively inhibiting CDK1, CDK2, CDK5 and CDK9 with IC50 values of 3, 1, 1 and 4 nM respectively.

Availability: In stock

Package Price Qty
5 mg
$70.00
10 mg
$120.00
25 mg
$240.00
50 mg
$380.00
10mM * 1mL in DMSO
$80.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Washio I, .et al. Impact of Breast Cancer Resistance Protein Expression on the In Vitro Efficacy of Anticancer Drugs in Pancreatic Cancer Cell Lines, Drug Metab Dispos, 2018, Mar;46(3):214-222 PMID: 29246888

Biological Activity

Dinaciclib (SCH 727965) is a potent and selective cyclin-dependent kinase (CDK) inhibitor, selectively inhibiting CDK1, CDK2, CDK5 and CDK9 with IC50 values of 3, 1, 1 and 4 nM respectively.
Targets
CDK2 (Cell-free assay) CDK5 (Cell-free assay) CDK1 (Cell-free assay) CDK9 (Cell-free assay)
1 nM1 nM3 nM4 nM
In vitro (25°C) DMSO 26 mg/mL heating (65.57 mM)
Water <1 mg/mL (<1 mM)
Ethanol 8 mg/mL heating (20.17 mM)
In vivo 15% Captisol 6 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.22 mL 126.1 mL 252.21 mL
0.5 mM 5.04 mL 25.22 mL 50.44 mL
1 mM 2.52 mL 12.61 mL 25.22 mL
5 mM 0.5 mL 2.52 mL 5.04 mL

*The above data is based on the productmolecular weight 396.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11129
Actions Inhibitor
M. Wt 396.5
Formula C21H28N6O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 779353-01-4
Synonyms SCH727965, SCH-727965
SMILES CCC1=C2N=C(C=C(N2N=C1)NCC3=C[N+](=CC=C3)[O-])N4CCCC[[email protected]]4CCO

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