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Dinaciclib (SCH 727965)

Dinaciclib (SCH 727965)

Name: Dinaciclib (SCH 727965)
SKU: A11129

Catalog No.: A11129

CDK Inhibitor

Product Citations (1)

Dinaciclib (SCH 727965) Chemical Structure

CAS NO. 779353-01-4

Dinaciclib (SCH 727965) is a potent and selective cyclin-dependent kinase (CDK) inhibitor, selectively inhibiting CDK1, CDK2, CDK5 and CDK9 with IC50 values of 3, 1, 1 and 4 nM respectively.

Availability: In stock

Package	Price	Qty
5 mg	Regular Price: $70.00 Special Price $63.00
10 mg	Regular Price: $120.00 Special Price $108.00
25 mg	Regular Price: $240.00 Special Price $216.00
50 mg	Regular Price: $380.00 Special Price $342.00
10mM * 1mL in DMSO	Regular Price: $80.00 Special Price $72.00

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Biological Activity

Dinaciclib (SCH 727965) is a potent and selective cyclin-dependent kinase (CDK) inhibitor, selectively inhibiting CDK1, CDK2, CDK5 and CDK9 with IC50 values of 3, 1, 1 and 4 nM respectively.

Targets

CDK2 (Cell-free assay)	CDK5 (Cell-free assay)	CDK1 (Cell-free assay)	CDK9 (Cell-free assay)
1 nM	1 nM	3 nM	4 nM

Solubility *

In vitro (25°C)	DMSO	26 mg/mL heating (65.57 mM)
	Water	<1 mg/mL (<1 mM)
	Ethanol	8 mg/mL heating (20.17 mM)
In vivo	15% Captisol	6 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.22 mL	126.1 mL	252.21 mL
0.5 mM	5.04 mL	25.22 mL	50.44 mL
1 mM	2.52 mL	12.61 mL	25.22 mL
5 mM	0.5 mL	2.52 mL	5.04 mL

*The above data is based on the productmolecular weight 396.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A11129
Actions	Inhibitor
M. Wt	396.5
Formula	C21H28N6O2
Solubility	DMSO
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	779353-01-4
Synonyms	SCH727965, SCH-727965
SMILES	CCC1=C2N=C(C=C(N2N=C1)NCC3=C[N+](=CC=C3)[O-])N4CCCC[[email protected]]4CCO