Dinaciclib (SCH 727965)

Name: Dinaciclib (SCH 727965)
Brand: Adooq Bioscience
SKU: A11129
Rating: 100 (3 reviews)

Catalog No.: A11129

CDK Inhibitor

Product Citations (3)

Dinaciclib (SCH 727965) Chemical Structure

CAS NO. 779353-01-4

Dinaciclib (SCH 727965) is a potent and selective cyclin-dependent kinase (CDK) inhibitor, selectively inhibiting CDK1, CDK2, CDK5 and CDK9 with IC50 values of 3, 1, 1 and 4 nM respectively.

Availability: In stock

Package	Price	Qty
5 mg	$70.00
10 mg	$120.00
25 mg	$240.00
50 mg	$380.00
10mM * 1mL in DMSO	$80.00
Custom Size	Get quote

Free Overnight Delivery on orders over $500

Next day delivery by 10:00 a.m. Order now.

Bulk Inquiry

Get Free Sample

Price Match

Add to Wishlist

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq Dinaciclib (SCH 727965)

Sepideh Izadi, .et al. Codelivery of HIF-1α siRNA and Dinaciclib by Carboxylated Graphene Oxide-Trimethyl Chitosan-Hyaluronate Nanoparticles Significantly Suppresses Cancer Cell Progression, Pharm Res, 2020, Sep 17;37(10):196 PMID: 32944844
Shahin Hallaj, .et al. Inhibition of CD73 using folate targeted nanoparticles carrying anti-CD73 siRNA potentiates anticancer efficacy of Dinaciclib, Life Sci, 2020, Jul 26 PMID: 32726663
Washio I, .et al. Impact of Breast Cancer Resistance Protein Expression on the In Vitro Efficacy of Anticancer Drugs in Pancreatic Cancer Cell Lines, Drug Metab Dispos, 2018, Mar;46(3):214-222 PMID: 29246888

Biological Activity

Dinaciclib (SCH 727965) is a potent and selective cyclin-dependent kinase (CDK) inhibitor, selectively inhibiting CDK1, CDK2, CDK5 and CDK9 with IC50 values of 3, 1, 1 and 4 nM respectively.

Targets

CDK2 (Cell-free assay)	CDK5 (Cell-free assay)	CDK1 (Cell-free assay)	CDK9 (Cell-free assay)
1 nM	1 nM	3 nM	4 nM

Solubility *

In vitro (25°C)	DMSO	Warmed: 22 mg/mL (55.48 mM)
	Water	Insoluble
	Ethanol	Warmed: 7 mg/mL (17.65 mM)
In vivo	2% DMSO+30% PEG 300+ddH2O	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.22 mL	126.1 mL	252.21 mL
0.5 mM	5.04 mL	25.22 mL	50.44 mL
1 mM	2.52 mL	12.61 mL	25.22 mL
5 mM	0.5 mL	2.52 mL	5.04 mL

*The above data is based on the productmolecular weight 396.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A11129
Actions	Inhibitor
CAS No.	779353-01-4
Formula	C21H28N6O2
M. Wt	396.5
Purity	>98%
Synonyms	SCH727965, SCH-727965
SMILES	CCC1=C2N=C(C=C(N2N=C1)NCC3=C[N+](=CC=C3)[O-])N4CCCC[[email protected]]4CCO
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.