Dithranol

Catalog No.: A17404

Dithranol

Dithranol Chemical Structure

CAS NO. 1143-38-0

Anthralin, also known as Dithranol, is a hepsin activity inhibitor used for treatment of psoriasis Inhibition of hepsin activity suppresses the invasive growth of the tumor. Anthralin exerts a direct effect on keratinocytes and leukocytes. Anthralin significantly prolonged the prophase of mitotic keratinocytes in subtoxic doses and suppressed the expression of keratin 6 mRNA in the immediately suprabasal layer of psoriatic epidermis in vivo. Anthralin also inhibits the transformation of lymphocytes and the release of reactive oxygen species from activated leukocytes, in vitro.

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100 mg

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500 mg

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Biological Activity

Anthralin, also known as Dithranol, is a hepsin activity inhibitor used for treatment of psoriasis Inhibition of hepsin activity suppresses the invasive growth of the tumor. Anthralin exerts a direct effect on keratinocytes and leukocytes. Anthralin significantly prolonged the prophase of mitotic keratinocytes in subtoxic doses and suppressed the expression of keratin 6 mRNA in the immediately suprabasal layer of psoriatic epidermis in vivo. Anthralin also inhibits the transformation of lymphocytes and the release of reactive oxygen species from activated leukocytes, in vitro.
In vitro DMSO 6 mg/mL (26.52 mM)
Ethanol <1 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 44.2 mL 221.01 mL 442.03 mL
0.5 mM 8.84 mL 44.2 mL 88.41 mL
1 mM 4.42 mL 22.1 mL 44.2 mL
5 mM 0.88 mL 4.42 mL 8.84 mL

*The above data is based on the productmolecular weight 226.231. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A17404
CAS No. 1143-38-0
Formula C14H10O3
M. Wt 226.231
Purity >98%
Synonyms Anthralin; Batridol; Dithranol; NSC 629313; NSC-629313; NSC629313
SMILES O=C1C2=C(C=CC=C2O)CC3=CC=CC(O)=C13
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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