Dithranol

Catalog No.: A17404

Dithranol

Dithranol Chemical Structure

CAS NO. 1143-38-0

Anthralin, also known as Dithranol, is a hepsin activity inhibitor used for treatment of psoriasis Inhibition of hepsin activity suppresses the invasive growth of the tumor. Anthralin exerts a direct effect on keratinocytes and leukocytes. Anthralin significantly prolonged the prophase of mitotic keratinocytes in subtoxic doses and suppressed the expression of keratin 6 mRNA in the immediately suprabasal layer of psoriatic epidermis in vivo. Anthralin also inhibits the transformation of lymphocytes and the release of reactive oxygen species from activated leukocytes, in vitro.

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Biological Activity

Anthralin, also known as Dithranol, is a hepsin activity inhibitor used for treatment of psoriasis Inhibition of hepsin activity suppresses the invasive growth of the tumor. Anthralin exerts a direct effect on keratinocytes and leukocytes. Anthralin significantly prolonged the prophase of mitotic keratinocytes in subtoxic doses and suppressed the expression of keratin 6 mRNA in the immediately suprabasal layer of psoriatic epidermis in vivo. Anthralin also inhibits the transformation of lymphocytes and the release of reactive oxygen species from activated leukocytes, in vitro.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 44.2 mL 221.01 mL 442.03 mL
0.5 mM 8.84 mL 44.2 mL 88.41 mL
1 mM 4.42 mL 22.1 mL 44.2 mL
5 mM 0.88 mL 4.42 mL 8.84 mL

*The above data is based on the productmolecular weight 226.231. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A17404
M. Wt 226.231
Formula C14H10O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1143-38-0
Synonyms Anthralin; Batridol; Dithranol; NSC 629313; NSC-629313; NSC629313
SMILES O=C1C2=C(C=CC=C2O)CC3=CC=CC(O)=C13

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