DNMT1-IN-4 is a potent non-nucleoside inhibitor of DNA methyltransferase 1 (DNMT1), exhibiting an IC50 value of 2.5 µM. This compound demonstrates selective inhibition of DNMT1 over other AdoMet-dependent protein methyltransferases. DNMT1-IN-4 effectively reduces cancer cell proliferation, making it a valuable tool for investigating the role of DNA methylation in cancer biology and epigenetic research.
DNMT1-IN-4 is a potent non-nucleoside inhibitor of DNA methyltransferase 1 (DNMT1), exhibiting an IC50 value of 2.5 µM. This compound demonstrates selective inhibition of DNMT1 over other AdoMet-dependent protein methyltransferases. DNMT1-IN-4 effectively reduces cancer cell proliferation, making it a valuable tool for investigating the role of DNA methylation in cancer biology and epigenetic research.
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