DNMT3A-IN-1 is a selective inhibitor of the DNA methyltransferase 3A (DNMT3A) enzyme. It exhibits inhibitory activity with KI values between 9.16 to 18.85 μM when measured with AdoMet and 11.37 to 23.34 μM using poly dI-dC. This compound has been shown to induce apoptosis in acute myeloid leukemia (AML) cell lines, making it a valuable tool in the study of epigenetic regulation and potential therapeutic applications in cancer research.
DNMT3A-IN-1 is a selective inhibitor of the DNA methyltransferase 3A (DNMT3A) enzyme. It exhibits inhibitory activity with KI values between 9.16 to 18.85 μM when measured with AdoMet and 11.37 to 23.34 μM using poly dI-dC. This compound has been shown to induce apoptosis in acute myeloid leukemia (AML) cell lines, making it a valuable tool in the study of epigenetic regulation and potential therapeutic applications in cancer research.
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