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Dolastatinol

Catalog No.: A55012
Microtubule/Tubulin Inhibitor
Dolastatinol is a synthetic analog of dolastatin 10 that acts as a potent inhibitor of tubulin polymerization. Its low nanomolar activity effectively disrupts microtubule formation, leading to significant effects on cell division and proliferation. This compound is valuable for research applications in cancer biology and studies investigating microtubule dynamics.
Dolastatinol 2759918-83-5 Microtubule/Tubulin Inhibitor
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionDolastatinol is a synthetic analog of dolastatin 10 that acts as a potent inhibitor of tubulin polymerization. Its low nanomolar activity effectively disrupts microtubule formation, leading to significant effects on cell division and proliferation. This compound is valuable for research applications in cancer biology and studies investigating microtubule dynamics.
Product Information
Catalog NumA55012
FormulaC43H70N6O7S
Molecular Weight815.12
CAS Number2759918-83-5
SMILESOCC1=CSC([C@H](CC2=CC=CC=C2)NC([C@@H](C)[C@@H]([C@]3([H])N(CCC3)C(C[C@H](OC)[C@H]([C@H](C)CC)N(C)C([C@@H](C(C)C)NC([C@H](N(C)C)C(C)C)=O)=O)=O)OC)=O)=N1
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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Cytoskeleton > Microtubule/Tubulin