Doxazosin

Catalog No.: A17779

α-1 adrenergic receptor blocker

Doxazosin

Doxazosin Chemical Structure

CAS NO. 74191-85-8

Doxazosin is an α-1 adrenergic receptor blocker that inhibits the binding of norepinephrine, which is released from sympathetic nerve terminals, to the α-1 receptors on the membrane of vascular smooth muscle cells. Blockages of the alpha-1 adrenergic action on the vascular smooth muscles lead to a decrease in vascular resistance and antihypertensive activity.

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100 mg
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500 mg
$120.00
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Biological Activity

Doxazosin is an α-1 adrenergic receptor blocker that inhibits the binding of norepinephrine, which is released from sympathetic nerve terminals, to the α-1 receptors on the membrane of vascular smooth muscle cells. Blockages of the alpha-1 adrenergic action on the vascular smooth muscles lead to a decrease in vascular resistance and antihypertensive activity.
In vitro DMSO 29 mg/mL (64.23 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.15 mL 110.75 mL 221.49 mL
0.5 mM 4.43 mL 22.15 mL 44.3 mL
1 mM 2.21 mL 11.07 mL 22.15 mL
5 mM 0.44 mL 2.21 mL 4.43 mL

*The above data is based on the productmolecular weight 451.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A17779
Actions Blocker
CAS No. 74191-85-8
Formula C23H25N5O5
M. Wt 451.48
Purity >98%
Synonyms Doxazosin; Cardura; 74191-85-8; Doxazosinum; Doxazosina; Doxazosine; Alfamedin; Aliud Brand of Doxazosin Mesylate; Almirall Brand of Doxazosin Mesylate; Alpharma Brand of Doxazosin Mesylate; Alter Brand of Doxazosin Mesylate; Apo Doxazosin; Apo-Doxazosin;
SMILES COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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