DPI-4452 is a CAIX-targeting cyclic peptide incorporating a DOTA cage, designed for chelation with radionuclides for positron emission tomography-computed tomography (PET-CT) imaging of CAIX-expressing tumors. This compound exhibits high specificity by binding to the carbonic anhydrase IX (CAIX) with an IC50 of 130 nM, while showing no significant interactions with a panel of 55 off-target receptors. In preclinical studies, radiolabeled DPI-4452 effectively inhibits tumor growth in HT-29 and SK-RC-52 xenograft mouse models. Additionally, it serves as a valuable reagent for the research and development of Radionuclide-Drug Conjugates (RDCs).
DPI-4452 is a CAIX-targeting cyclic peptide incorporating a DOTA cage, designed for chelation with radionuclides for positron emission tomography-computed tomography (PET-CT) imaging of CAIX-expressing tumors. This compound exhibits high specificity by binding to the carbonic anhydrase IX (CAIX) with an IC50 of 130 nM, while showing no significant interactions with a panel of 55 off-target receptors. In preclinical studies, radiolabeled DPI-4452 effectively inhibits tumor growth in HT-29 and SK-RC-52 xenograft mouse models. Additionally, it serves as a valuable reagent for the research and development of Radionuclide-Drug Conjugates (RDCs).
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