DSR-141562 is a selective inhibitor of phosphodiesterase 1 (PDE1), demonstrating a primary mechanism of action through the inhibition of PDE1B with an IC50 of 43.9 nM. This compound also exhibits lower affinity for PDE1A and PDE1C, with IC50 values of 97.6 nM and 431.8 nM, respectively. DSR-141562 is useful for investigating the positive and negative symptoms, as well as cognitive impairments associated with schizophrenia, making it a valuable tool in psychiatric research.
DSR-141562 is a selective inhibitor of phosphodiesterase 1 (PDE1), demonstrating a primary mechanism of action through the inhibition of PDE1B with an IC50 of 43.9 nM. This compound also exhibits lower affinity for PDE1A and PDE1C, with IC50 values of 97.6 nM and 431.8 nM, respectively. DSR-141562 is useful for investigating the positive and negative symptoms, as well as cognitive impairments associated with schizophrenia, making it a valuable tool in psychiatric research.
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