DSR-71167 is an orally active mineralocorticoid receptor antagonist exhibiting an IC50 of 0.26 μM. This compound displays weak carbonic anhydrase inhibitory activity with an IC50 of 19 μM. DSR-71167 has demonstrated the ability to dose-dependently enhance urinary sodium excretion and effectively lowers systolic blood pressure in hypertensive rat models, while presenting a low risk of hyperkalemia in potassium-loading scenarios. It is suitable for research focused on hypertension and heart failure.
DSR-71167 is an orally active mineralocorticoid receptor antagonist exhibiting an IC50 of 0.26 μM. This compound displays weak carbonic anhydrase inhibitory activity with an IC50 of 19 μM. DSR-71167 has demonstrated the ability to dose-dependently enhance urinary sodium excretion and effectively lowers systolic blood pressure in hypertensive rat models, while presenting a low risk of hyperkalemia in potassium-loading scenarios. It is suitable for research focused on hypertension and heart failure.
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