DY3002 is a highly selective and potent EGFR inhibitor specifically designed to target T790M-mutated variants associated with non-small cell lung cancer. This compound demonstrates a remarkable inhibitory effect on EGFR T790M mutants with an IC50 of 0.71 nM, while exhibiting significantly reduced activity against wild-type EGFR (IC50 = 448.7 nM). In cellular assays, DY3002 shows an IC50 of 0.037 μM against H1975 cells, indicating enhanced biological efficacy. Additionally, DY3002 maintains an extraordinary selectivity index (SI = 632.0) and does not induce hyperglycemia, making it a promising candidate for further research in overcoming drug resistance in cancer therapy.
DY3002 is a highly selective and potent EGFR inhibitor specifically designed to target T790M-mutated variants associated with non-small cell lung cancer. This compound demonstrates a remarkable inhibitory effect on EGFR T790M mutants with an IC50 of 0.71 nM, while exhibiting significantly reduced activity against wild-type EGFR (IC50 = 448.7 nM). In cellular assays, DY3002 shows an IC50 of 0.037 μM against H1975 cells, indicating enhanced biological efficacy. Additionally, DY3002 maintains an extraordinary selectivity index (SI = 632.0) and does not induce hyperglycemia, making it a promising candidate for further research in overcoming drug resistance in cancer therapy.
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