E3 ligase Ligand 63-N-CH2-Ph-O-CH3

Catalog No.: A80385
E3 Ligase Ligand-Linker Conjugate
E3 Ligase Ligand 63-N-CH2-Ph-O-CH3 is an E3 ligase ligand-linker conjugate that incorporates a CRBN-based ligand and a flexible linker. This compound is designed for the synthesis of PROTACs (proteolysis-targeting chimeras), facilitating targeted protein degradation. Its unique structure supports the recruitment of E3 ligases to target proteins, enabling efficient modulation of protein levels in various research applications, including cancer therapy and cellular signaling studies.
Grouped product items
Size Price Stock Qty
100mg
$40.00
In stock
250mg
$80.00
In stock
500mg
$140.00
In stock
1g
$235.00
In stock
5g
$865.00
In stock
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionE3 Ligase Ligand 63-N-CH2-Ph-O-CH3 is an E3 ligase ligand-linker conjugate that incorporates a CRBN-based ligand and a flexible linker. This compound is designed for the synthesis of PROTACs (proteolysis-targeting chimeras), facilitating targeted protein degradation. Its unique structure supports the recruitment of E3 ligases to target proteins, enabling efficient modulation of protein levels in various research applications, including cancer therapy and cellular signaling studies.
Product Information
Catalog NumA80385
FormulaC21H20BrN3O4
Molecular Weight458.31
CAS Number2357109-91-0
SMILESO=C1N(C=2C(Br)=CC=CC2N1C3C(=O)N(C(=O)CC3)CC4=CC=C(OC)C=C4)C
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