E3 Ligase Ligand-Linker Conjugate 183 is designed to target E3 ligases, facilitating the selective degradation of protein substrates through the ubiquitin-proteasome system. This conjugate features the LC3B ligand 2, which enhances autophagic degradation, and an optimized linker for effective delivery. Its applications include studies on protein turnover, cellular homeostasis, and targeted protein degradation, particularly in the context of PCSK9 regulation.
E3 Ligase Ligand-Linker Conjugate 183 is designed to target E3 ligases, facilitating the selective degradation of protein substrates through the ubiquitin-proteasome system. This conjugate features the LC3B ligand 2, which enhances autophagic degradation, and an optimized linker for effective delivery. Its applications include studies on protein turnover, cellular homeostasis, and targeted protein degradation, particularly in the context of PCSK9 regulation.
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