EB-0150 is a selective inhibitor of endoplasmic reticulum α-glucosidases I and II, exhibiting IC50 values of 0.73 µM and 0.0337 µM, respectively. This N-substituted derivative of valiolamine demonstrates broad-spectrum antiviral activity and can be utilized in research aimed at developing agents against both existing and emerging viral pathogens. Additionally, EB-0150 serves as a versatile click chemistry reagent, possessing an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne-containing and DBCO or BCN-labeled molecules.
EB-0150 is a selective inhibitor of endoplasmic reticulum α-glucosidases I and II, exhibiting IC50 values of 0.73 µM and 0.0337 µM, respectively. This N-substituted derivative of valiolamine demonstrates broad-spectrum antiviral activity and can be utilized in research aimed at developing agents against both existing and emerging viral pathogens. Additionally, EB-0150 serves as a versatile click chemistry reagent, possessing an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne-containing and DBCO or BCN-labeled molecules.
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