Catalog No.
Product Name
Application
Product Information
Citations
- Miglitol inhibits glycoside hydrolase enzymes called alpha-glucosidases. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the body.
- Miglustat hydrochloride is an orally active α-glucosidase I and II and ceramide-specific glycosyltransferase inhibitor.
- Sayaka Tsuda, .et al. , J.Hard Tissue Biology, 2025, Vol. 34(1): 1-8
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alpha-glucosidase I inhibitor
Celgosivir is an alpha-glucosidase I inhibitor for the potential treatment of HCV infection. -
glucosidase I/II inhibitor
Deoxynojirimycin is a Maltase-glucoamylase (a-glucosidase I and II) inhibitor. It interferes with N-linked glycosylation. - Afegostat D-tartrate was an experimental drug for the treatment of certain forms of Gaucher's disease. The substance was used in form of the tartrate. Isofagomine (IFG) is an acid β-glucosidase (GCase) active site inhibitor that acts as a pharmacological chaperone.
- 3-butylidenephthalide from Ligusticum porteri , an α-glucosidase inhibitor.
- Licochalcone C was synthesized from commercially available 2,4-dihydroxybenzaldehde by using regioselective Al2O3-mediated C-prenylation followed by conventional Claisen-Schmidt condensation in basic condition.
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α-glucosidase inhibitor
Hexylresorcinol (4-Hexylresorcinol) is a natural compound found in plants with antimicrobial, anthelmintic, antiseptic and antitumor activities. Hexylresorcinol can induce apoptosis in squamous carcinoma cells. Hexylresorcinol is a reversible and noncompetitive inhibitor of α-glucosidase. Hexylresorcinol has protective effects against oxidative DNA damage. - Terphenyllin is a naturally abundant p-terphenyl metabolite isolated from the coral derived fungus Aspergillus candidus, has signi?cant α-glucosidase inhibitory activity.
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alpha-glucosidase/alpha-1,6-glucosidase inhibitor
N-Nonyldeoxynojirimycin (NN-DNJ) is a potent inhibitor of alpha-glucosidase and alpha-1,6-glucosidase (IC50s, 0.42, 8.4 μM, respectively), inhibits glycogen breakdown. -
GCase inhibitor
Conduritol B epoxide is an irreversible covalently bound acid β-glucosidase (GCase) inhibitor. -
α-glucosidase inhibitor
Butyl isobutyl phthalate is isolated from the rhizoid of Laminaria japonica. Butyl isobutyl phthalate is a non-competitive α-glucosidase inhibitor with an IC50 value of 38 μM. -
α-glucosidase inhibitory activities
Tangshenoside I, isolated from the roots of Codonopsis lanceolata, exhibits weak α-glucosidase inhibitory activities in vitro with an IC50 of 1.4 mM. -
COX-1/HDAC/Tyrosinase Inhibitor
Gnetol is a bioactive phenolic compound isolated from the root of *Gnetum montanum* with diverse pharmacological properties. It potently inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 0.78 μM and exhibits histone deacetylase (HDAC) inhibitory activity. Gnetol is also a strong tyrosinase inhibitor, with an IC₅₀ of 4.5 μM against murine tyrosinase, leading to suppression of melanin biosynthesis. In addition to its antioxidant, antiproliferative, anticancer, and hepatoprotective effects, Gnetol modulates metabolic enzymes in a concentration-dependent manner, including α-amylase, α-glucosidase, and adipogenesis pathways, making it a promising candidate for research in oncology, dermatology, and metabolic disorders. -
Antioxidant
4,5-Dicaffeoylquinic acid is a potent antioxidant primarily targeting cellular oxidative stress. This compound, derived from Gynura divaricata and Laggera alata, exhibits significant biological activities, including the reduction of islet cell apoptosis and enhancement of pancreatic function in type 2 diabetic models. It effectively inhibits yeast α-glucosidase and demonstrates anti-cancer properties through cell cycle arrest in prostate cancer cells. Additionally, 4,5-Dicaffeoylquinic acid possesses anti-apoptotic effects and shows potential in protecting against liver injury and hepatitis B virus infection, making it valuable in various research applications. -
Anti-inflammation/Infection Agent
β-Amyrone is a triterpene compound recognized for its anti-inflammatory properties, primarily through the inhibition of cyclooxygenase-2 (COX-2) expression. It demonstrates significant antifungal activity and exhibits antiviral effects against the Chikungunya virus. Additionally, β-Amyrone inhibits α-glucosidase and acetylcholinesterase (AChE) activities, making it a valuable compound for research in inflammation, infectious diseases, and obesity-related studies. -
Antifungal Agent
Eleutherol is a naphthalene derivative derived from E. americana, exhibiting significant antifungal properties. It effectively targets various yeast species, including Candida albicans, C. tropicalis, Saccharomyces cerevisiae, and Cryptococcus neoformans, with minimum inhibitory concentration (MIC) values ranging from 7.8 µg/mL to 250 µg/mL. Additionally, Eleutherol inhibits α-glucosidase activity, presenting an IC50 greater than 1.00 mM, indicating its potential for further research in antifungal applications and enzyme inhibition studies. -
Partial PPARγ Agonist
Oroxin A is a partial agonist of the peroxisome proliferator-activated receptor gamma (PPARγ). It enhances PPARγ transcriptional activity through binding to the PPARγ ligand-binding domain. Additionally, Oroxin A demonstrates inhibitory effects on α-glucosidase and possesses antioxidant properties. Its anti-breast cancer potential is attributed to the induction of endoplasmic reticulum stress-mediated cellular senescence, making it a valuable tool for research in metabolic and cancer biology. -
Anti-inflammatory Agent
(-)-Pinoresinol is a plant-derived tetrahydrofuran lignan that serves as an anti-inflammatory agent through the inhibition of α-glucosidase. This compound exhibits hypoglycemic properties and demonstrates chemopreventive potential by inducing apoptosis and causing G2/M phase cell cycle arrest. Its biological activities make it a valuable tool for research in inflammation and metabolic disorders. -
α-Glucosidase Inhibitor
Malabaricone B is a naturally occurring phenolic compound that functions as an α-glucosidase inhibitor, exhibiting an IC50 of 63.7 µM. This compound demonstrates significant biological activities, including anticancer, antimicrobial, antioxidant, and antidiabetic effects. It is suitable for research applications focused on metabolic regulation and the investigation of glycemic control. -
Antitumor
3-Hydroxybakuchiol is an electron transport chain (ETC) inhibitor known for its antitumor properties. It effectively induces apoptosis in tumor cells, contributing to its potential as a therapeutic agent in cancer research. Additionally, 3-Hydroxybakuchiol exhibits moderate inhibitory activity against α-glucosidase, with an IC50 value of 345 μM, further expanding its applications in biological studies. -
PTP1B Inhibitor
Caffeoyltryptophan is a competitive inhibitor of protein tyrosine phosphatase 1B (PTP1B), exhibiting an IC50 of 16.99 μM. Additionally, it demonstrates inhibitory effects on α-glucosidase, linoleic acid peroxidation, and hemolysis. This compound is primarily utilized in research related to type 2 diabetes, offering insights into metabolic regulation and potential therapeutic avenues. -
DPP-4 Inhibitor
Antidiabetic agent 2 is a potent DPP-4 inhibitor that effectively promotes glucose uptake. This compound also inhibits PTP-1B, α-amylase, and α-glucosidase, exhibiting IC50 values of 0.036, 0.042, 0.241, and 0.185 μM, respectively. By decreasing blood glucose levels, Antidiabetic agent 2 serves as a valuable tool for research focused on diabetes management and the modulation of glucose homeostasis. -
Ethyl Caffeoylquinate
Ethyl-3,5-di-O-caffeoylquinate is a derivative of ethyl caffeoylquinate, primarily targeting α-glucosidase and PTP1B enzymes. This compound demonstrates potential as an inhibitor of these critical enzymes, making it valuable for research in metabolic disorders and diabetes management. Isolated from the flower buds of Lonicera macranthoides, it also serves as an isomer of chlorogenic acid (ethyl dicaffeoylquinate), expanding its relevance in phytochemical studies and pharmacological applications. -
Phosphatase Inhibitor
Chrysophanol triglucoside is an anthraquinone with a specific inhibitory action on protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase, demonstrating IC50 values of 80.17 µM and 197.06 µM, respectively. This compound is derived from Cassia obtusifolia and has potential applications in diabetes research, particularly in the study of glucose metabolism and insulin signaling pathways. -
Prenylated Flavonoid
Parvisoflavone B is a prenylated flavonoid that selectively inhibits protein tyrosine phosphatase 1B (PTP1B) with an IC50 of 42.6 μM and α-glucosidase with an IC50 of 12.19 μM. This compound is derived from the root bark of Erythrina mildbraedii and exhibits significant biological activity relevant to metabolic disorders. Parvisoflavone B is utilized in research exploring mechanisms related to type 2 diabetes and obesity, making it a valuable tool for studying these conditions. -
Anti-Inflammatory/Cancer Agent
Norathyriol is a natural metabolite derived from Mangifera, exhibiting significant anti-inflammatory and anticancer properties. It functions as a noncompetitive inhibitor of α-glucosidase with an IC50 value of 3.12 μM. Additionally, Norathyriol inhibits the peroxisome proliferator-activated receptors (PPARs) α, β, and γ, with IC50s of 92.8 μM, 102.4 μM, and 153.5 μM, respectively. This compound demonstrates a range of biological activities, including antioxidant, antimicrobial, and antibacterial effects, making it valuable for diverse research applications in inflammation and cancer therapeutics. -
Phenolic Compound
Brevifolincarboxylic acid is a phenolic compound that targets α-glucosidase, inhibiting its activity with an IC50 value of 323.46 μM. This compound exhibits an inhibitory effect on the aryl hydrocarbon receptor (AhR) and possesses antioxidant properties by scavenging reactive oxygen species (ROS). Additionally, it enhances glucose uptake in myotubes and demonstrates antitumor activity against lung and gastric cancers. Brevifolincarboxylic acid is valuable for research in diabetes and inflammatory diseases. -
α-Glucosidase Inhibitor
Guavinoside B is an orally active α-glucosidase inhibitor, exhibiting an IC50 of 0.21 mM. It demonstrates significant biological activity by upregulating the expressions of Nrf2, GCLC, and NQO1 while downregulating p-JNK expression and reducing intracellular reactive oxygen species levels. Guavinoside B effectively decreases serum TNF-α levels associated with Acetaminophen, alleviating hepatocellular infiltration and necrosis, and improving liver-related biochemical parameters. This compound is relevant for research in diabetes and Acetaminophen-induced liver injury. -
Antioxidant
1,2-Diacetoxy-4,7,8-trihydroxy-3-(4-hydroxyphenyl)dibenzofuran is an antioxidant compound derived from the edible mushroom Sarcodon leucopus. It exhibits significant free radical scavenging activity, demonstrated by an IC50 of 28 μM in the DPPH assay. Additionally, it effectively inhibits malondialdehyde (MDA) formation with an IC50 of 71 μM and α-glucosidase activity with an IC50 of 6.22 μM, making it a valuable reagent for studies in antioxidant research and metabolic disorders. -
Pancreatic Lipase/Acetylcholinesterase/Glutamic-oxaloacetic Transaminase 1/Alpha-glucosidase Inhibitor
Aspulvinone H is a potent inhibitor targeting pancreatic lipase, acetylcholinesterase, glutamic-oxaloacetic transaminase 1 (GOT1), and α-glucosidase, with IC50 values of 25.95 μM, 47.06 μM, 5.91/6.91 μM, and 4.6 μM, respectively. It demonstrates key biological activities including inhibition of cancer cell proliferation, disruption of glutamine metabolism, and induction of apoptosis in cancer cells. Additionally, Aspulvinone H lowers postprandial blood glucose levels in mice and exhibits antibacterial properties against Staphylococcus aureus. This compound is suitable for research into pancreatic ductal adenocarcinoma, diabetes management, and infectious diseases caused by Staphylococcus aureus. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-63 is a potent inhibitor of α-Glucosidase, displaying an IC50 value of 0.44 μM. Additionally, it inhibits human carbonic anhydrase II (hCA II) with a Ki of 7.0 nM. This compound is of interest for research applications focusing on glucose metabolism and enzymatic regulation in metabolic disorders. Its oral effectiveness enhances its utility in in vivo studies. -
Cellotriose Analog
4-Nitrophenyl β-D-Cellobioside is a cellotriose analog primarily targeted by β-glucosidases, including TxGH116 and ThCel7B. This compound serves as a substrate in enzymatic assays to evaluate cellulase activity through the hydrolysis process, resulting in the release of p-nitrophenol (PNP). Its utility in research applications includes the study of cellulose degradation and enzyme kinetics, contributing valuable insights into carbohydrate metabolism and enzyme specificity. -
Fluorescent Dye
3-Acetylumbelliferyl β-D-Glucopyranoside serves as a fluorogenic substrate specifically for β-glucosidase, facilitating the detection of enzymatic activity through fluorescence. This compound is valuable as a positive control in assays involving β-D-glucosidase, enabling researchers to evaluate enzyme function and activity in various biological systems. Its application in fluorescence-based assays enhances the understanding of β-glucosidase involvement in numerous biological processes. -
Triterpenoid
Cyclocarin A is a triterpenoid compound isolated from the leaves of Cyclocarya paliurus. This compound exhibits weak inhibitory activity against several enzymes, including α-glucosidase, lipase, DPP-IV, and aldose reductase, along with limited effects on human cancer cell lines (IC50 > 10 μM). Despite its modest biological activity, Cyclocarin A may serve as a useful tool for research in enzyme inhibition and cancer biology. -
Antidiabetic Compound
Lupinalbin A, a dipeptidyl peptidase 4 (DPP4) and α-glucosidase inhibitor, demonstrates effective inhibition with IC50 values of 45.2 µM and 53.4 µM, respectively. This compound exhibits notable antidiabetic activity, making it a valuable tool for research in diabetes management and metabolic studies. Its dual inhibition profile supports investigations into glucose metabolism and insulin sensitivity. -
PKCα Inhibitor
Leucosceptoside A is a phenylethanoid glycoside that functions as a selective inhibitor of Protein Kinase C alpha (PKCα). This compound demonstrates significant anti-hyperglycemic and anti-hypertensive effects and exhibits inhibitory activity against α-glucosidase, with an IC50 value of 19.0 μM. Leucosceptoside A is relevant for research into metabolic disorders and cardiovascular diseases, providing insights into therapeutic approaches targeting PKCα. -
α-Glucosidase Inhibitor
CKD-711 is an orally active aminooligosaccharide that functions as a potent inhibitor of α-glucosidase, with an IC50 of 78 μg/mL. It also demonstrates inhibitory effects against porcine intestinal maltase and sucrose, with IC50 values of 2.5 and 0.5 μg/mL, respectively. Additionally, CKD-711 exhibits selective antibacterial activity against Comamonas terrigena. This compound is valuable for research into infections and metabolic disorders, including diabetes. -
Antimicrobial Agent
Methyl caffeate is an antimicrobial agent primarily known for its moderate antimicrobial and significant antimycobacterial activities. It also demonstrates α-glucosidase inhibition, oxidative stress reduction, and anti-platelet effects. Additionally, methyl caffeate exhibits antiproliferative properties in cervical adenocarcinoma and anticancer effects across lung and leukemia cell lines, making it a valuable reagent for various biochemical and pharmacological studies. -
α-glucosidase Inhibitor
1-Deoxynojirimycin hydrochloride is a potent α-glucosidase inhibitor, primarily utilized for modulating postprandial blood glucose levels. This compound demonstrates notable antihyperglycemic and anti-obesity effects, making it valuable in diabetes mellitus research. Additionally, 1-Deoxynojirimycin hydrochloride exhibits antiviral properties, contributing to its diverse applicability in metabolic and infectious disease studies. -
Cephalosporin Antibiotic
Cefetecol is a broad-spectrum cephalosporin antibiotic that targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall synthesis, leading to cell lysis. In addition to its antibacterial properties, Cefetecol also acts as an α-glucosidase inhibitor, demonstrating in vivo anti-diabetic activity in diabetic mouse models. This compound is suitable for research applications in both antibacterial and anti-diabetic studies. -
α-Glucosidase Inhibitor
DNJ-20 is an α-glucosidase inhibitor with an IC50 of 55.3 μg/mL, demonstrating significant broad-spectrum activity against SARS-CoV-2. It disrupts the endoplasmic reticulum-associated glycoprotein folding process, inhibiting proper processing of viral glycoproteins and consequently blocking viral particle formation and infection. DNJ-20 exhibits IC50 values as low as 1.49 μM against various SARS-CoV-2 variants, as well as HCoV-229E and HCoV-OC43. This inhibitor is suited for pan-coronavirus research applications.
