EC1169 is a PSMA-targeted maytansinoid conjugate that selectively binds to prostate-specific membrane antigen (PSMA). This compound delivers the cytotoxic maytansinoid B hydrazide payload directly to PSMA-positive tumor cells, demonstrating significant antitumor activity while sparing PSMA-negative cells. In preclinical models, EC1169 promotes complete recovery in mice with PSMA-positive tumors, exhibiting a favorable safety profile without inducing body weight loss or major organ damage. This reagent is valuable for research focused on prostate cancer and other PSMA-expressing malignancies.
EC1169 is a PSMA-targeted maytansinoid conjugate that selectively binds to prostate-specific membrane antigen (PSMA). This compound delivers the cytotoxic maytansinoid B hydrazide payload directly to PSMA-positive tumor cells, demonstrating significant antitumor activity while sparing PSMA-negative cells. In preclinical models, EC1169 promotes complete recovery in mice with PSMA-positive tumors, exhibiting a favorable safety profile without inducing body weight loss or major organ damage. This reagent is valuable for research focused on prostate cancer and other PSMA-expressing malignancies.
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