Efipladib is a selective inhibitor of cytosolic phospholipase A2 alpha (cPLA2α) with an IC50 of 0.04 μM and a Kd of 0.067 μM. This compound demonstrates significant inhibition of arachidonic acid release, contributing to its potential in modulating inflammatory responses. Efipladib is valuable for research applications aimed at understanding cPLA2α-driven pathways in various disease models, including neuroinflammation and cardiovascular conditions.
Efipladib is a selective inhibitor of cytosolic phospholipase A2 alpha (cPLA2α) with an IC50 of 0.04 μM and a Kd of 0.067 μM. This compound demonstrates significant inhibition of arachidonic acid release, contributing to its potential in modulating inflammatory responses. Efipladib is valuable for research applications aimed at understanding cPLA2α-driven pathways in various disease models, including neuroinflammation and cardiovascular conditions.
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