EG31 is a potent inhibitor of the epidermal growth factor receptor (EGFR), exhibiting strong antiproliferative effects on triple-negative breast cancer (TNBC) cells, with GI50 values of 498.90 nM for MDA-MB-231 and 740.73 nM for Hs578T cell lines. It effectively induces apoptosis by disrupting the EGFR signaling pathway. Additionally, EG31 retains its efficacy against 5-fluorouracil (5-FU)-resistant TNBC cells, demonstrating a GI50 of 519.5 nM. This compound is valuable for researching mechanisms of resistance in TNBC.
EG31 is a potent inhibitor of the epidermal growth factor receptor (EGFR), exhibiting strong antiproliferative effects on triple-negative breast cancer (TNBC) cells, with GI50 values of 498.90 nM for MDA-MB-231 and 740.73 nM for Hs578T cell lines. It effectively induces apoptosis by disrupting the EGFR signaling pathway. Additionally, EG31 retains its efficacy against 5-fluorouracil (5-FU)-resistant TNBC cells, demonstrating a GI50 of 519.5 nM. This compound is valuable for researching mechanisms of resistance in TNBC.
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