EGFR-IN-101 is a selective inhibitor of the epidermal growth factor receptor (EGFR). This compound demonstrates potent inhibitory activity with IC50 values of 33.26 nM against the EGFRL858R/T790M/C797S mutation and 106.4 nM in Ba/F3-EGFRL858R/T790M/C797S cells. EGFR-IN-101 is valuable for research applications focused on non-small cell lung cancer (NSCLC) and provides a framework for investigating resistance mechanisms and therapeutic strategies targeting EGFR mutations.
EGFR-IN-101 is a selective inhibitor of the epidermal growth factor receptor (EGFR). This compound demonstrates potent inhibitory activity with IC50 values of 33.26 nM against the EGFRL858R/T790M/C797S mutation and 106.4 nM in Ba/F3-EGFRL858R/T790M/C797S cells. EGFR-IN-101 is valuable for research applications focused on non-small cell lung cancer (NSCLC) and provides a framework for investigating resistance mechanisms and therapeutic strategies targeting EGFR mutations.
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