EGFR-IN-139 is a potent inhibitor of the epidermal growth factor receptor (EGFR) with IC50 values of 12.88 nM for wild type, 10.84 nM for L858R/T790M, and 42.68 nM for L858R/T790M/C797S mutants. This compound exhibits significant anticancer activity in A549 and H1975 cell lines, demonstrating strong selectivity for cancer cells that overexpress EGFR. EGFR-IN-139 is particularly relevant for research focused on nonsmall cell lung cancer (NSCLC).
EGFR-IN-139 is a potent inhibitor of the epidermal growth factor receptor (EGFR) with IC50 values of 12.88 nM for wild type, 10.84 nM for L858R/T790M, and 42.68 nM for L858R/T790M/C797S mutants. This compound exhibits significant anticancer activity in A549 and H1975 cell lines, demonstrating strong selectivity for cancer cells that overexpress EGFR. EGFR-IN-139 is particularly relevant for research focused on nonsmall cell lung cancer (NSCLC).
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