EGFR-IN-167 is a selective inhibitor of the epidermal growth factor receptor (EGFR), exhibiting an IC50 of 0.19 nM. This compound demonstrates high potency against various EGFR mutants, with IC50 values of 0.109 nM for EGFR (L858R), 0.75 nM for EGFR (C797S), and <0.05 nM for EGFR (del19). EGFR-IN-167 covalently binds to the catalytically conserved lysine residue in EGFR within live mammalian cells, effectively inhibiting EGFR autophosphorylation and showing significant anti-proliferative activity. This reagent is valuable for research in non-small-cell lung carcinomas (NSCLC), glioblastoma, and other solid tumors.
EGFR-IN-167 is a selective inhibitor of the epidermal growth factor receptor (EGFR), exhibiting an IC50 of 0.19 nM. This compound demonstrates high potency against various EGFR mutants, with IC50 values of 0.109 nM for EGFR (L858R), 0.75 nM for EGFR (C797S), and <0.05 nM for EGFR (del19). EGFR-IN-167 covalently binds to the catalytically conserved lysine residue in EGFR within live mammalian cells, effectively inhibiting EGFR autophosphorylation and showing significant anti-proliferative activity. This reagent is valuable for research in non-small-cell lung carcinomas (NSCLC), glioblastoma, and other solid tumors.
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