EGFR-IN-201 is a potent inhibitor of the epidermal growth factor receptor (EGFR), exhibiting an IC50 of 0.091 μM against wild-type EGFR. It demonstrates activity against mutant EGFR variants, with IC50 values of 0.147 μM for EGFRT790M, 0.221 μM for EGFRL858R, and 0.703 μM for EGFRC797S. Inhibition of downstream signaling pathways is evidenced by its IC50 values of 0.225 μg/mL for AKT1 and 0.705 μg/mL for ERK1. EGFR-IN-201 has been shown to induce G0/G1 cell cycle arrest, apoptosis, and low-level necrosis in cancer cells, making it a valuable tool for research in various cancer types, including colon cancer.
EGFR-IN-201 is a potent inhibitor of the epidermal growth factor receptor (EGFR), exhibiting an IC50 of 0.091 μM against wild-type EGFR. It demonstrates activity against mutant EGFR variants, with IC50 values of 0.147 μM for EGFRT790M, 0.221 μM for EGFRL858R, and 0.703 μM for EGFRC797S. Inhibition of downstream signaling pathways is evidenced by its IC50 values of 0.225 μg/mL for AKT1 and 0.705 μg/mL for ERK1. EGFR-IN-201 has been shown to induce G0/G1 cell cycle arrest, apoptosis, and low-level necrosis in cancer cells, making it a valuable tool for research in various cancer types, including colon cancer.
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