EGFR ligand-2 (compound C4) is a covalent inhibitor targeting the epidermal growth factor receptor (EGFR), exhibiting IC50 values of 21 nM for the EGFRL858R mutant and 48 nM for the EGFRL858R/T790M double mutant. This compound is useful in studying EGFR mutations associated with various cancers and can be utilized in the synthesis of PROTACs for targeted protein degradation research applications.
EGFR ligand-2 (compound C4) is a covalent inhibitor targeting the epidermal growth factor receptor (EGFR), exhibiting IC50 values of 21 nM for the EGFRL858R mutant and 48 nM for the EGFRL858R/T790M double mutant. This compound is useful in studying EGFR mutations associated with various cancers and can be utilized in the synthesis of PROTACs for targeted protein degradation research applications.
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