Eggmanone is a selective antagonist of phosphodiesterase 4 (PDE4), with an IC50 of 72 nM for the PDE4D3 isoform. This compound exhibits a remarkable 40- to 50-fold selectivity for PDE4D3 over other phosphodiesterases. By inhibiting PDE4, Eggmanone activates protein kinase A, resulting in the blockade of Hedgehog (Hh) signaling pathways. This biological activity makes Eggmanone a valuable tool for research into cellular signaling and potential therapeutic applications in conditions mediated by Hh pathways.
Eggmanone is a selective antagonist of phosphodiesterase 4 (PDE4), with an IC50 of 72 nM for the PDE4D3 isoform. This compound exhibits a remarkable 40- to 50-fold selectivity for PDE4D3 over other phosphodiesterases. By inhibiting PDE4, Eggmanone activates protein kinase A, resulting in the blockade of Hedgehog (Hh) signaling pathways. This biological activity makes Eggmanone a valuable tool for research into cellular signaling and potential therapeutic applications in conditions mediated by Hh pathways.
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