EHNA is a potent and selective dual inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2) and adenosine deaminase (ADA). It exhibits significant inhibition of cGMP-stimulated PDE2 activity, with an IC50 of 0.8 μM in human samples and 2 μM in porcine myocardium, while showing lesser effects on unstimulated PDE2. EHNA has been implicated in mediating various pharmacological responses, including antiviral, antitumor, and antiarrhythmic activities, making it a valuable tool for research in these domains.
EHNA is a potent and selective dual inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2) and adenosine deaminase (ADA). It exhibits significant inhibition of cGMP-stimulated PDE2 activity, with an IC50 of 0.8 μM in human samples and 2 μM in porcine myocardium, while showing lesser effects on unstimulated PDE2. EHNA has been implicated in mediating various pharmacological responses, including antiviral, antitumor, and antiarrhythmic activities, making it a valuable tool for research in these domains.
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