Endothelin (16-21)

Catalog No.: A60283
ETB Receptor Agonist
Endothelin (16-21) functions as a selective agonist for the ETB receptor, exhibiting an EC50 of 228 nM in guinea-pig bronchus. This compound effectively induces smooth muscle contraction, making it a valuable tool for studying respiratory conditions such as asthma and cardiovascular diseases, including hypertension. Its targeted mechanism provides insights into ETB receptor signaling pathways relevant to these medical research applications.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionEndothelin (16-21) functions as a selective agonist for the ETB receptor, exhibiting an EC50 of 228 nM in guinea-pig bronchus. This compound effectively induces smooth muscle contraction, making it a valuable tool for studying respiratory conditions such as asthma and cardiovascular diseases, including hypertension. Its targeted mechanism provides insights into ETB receptor signaling pathways relevant to these medical research applications.
Product Information
Catalog NumA60283
FormulaC39H57N9O9
Molecular Weight795.92
CAS Number121377-67-1
SequenceHis-Leu-Asp-Ile-Ile-Trp
Sequence shorteningHLDIIW
SMILESC([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CN=CN1)N)=O)CC(C)C)=O)CC(O)=O)=O)[C@H](CC)C)=O)[C@H](CC)C)=O)C(O)=O)C=2C=3C(NC2)=CC=CC3
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