Ent-Estradiol is a selective ligand for the estrogen receptors, specifically targeting both ERα and ERβ. As the enantiomer of 17β-Estradiol, it exhibits minimal estrogenic activity, making it valuable for studies that require the modulation of estrogen receptors without significant hormonal effects. Ent-Estradiol demonstrates varying inhibitory concentrations with IC50 values of 24.9 nM, 9.59 nM, and 8.17 nM for human, rat, and mouse ERβ, respectively, and 151 nM, 246 nM, and 268 nM for ERα across the same species. This compound is instrumental in researching menopausal physiological changes and receptor-specific mechanisms.
Ent-Estradiol is a selective ligand for the estrogen receptors, specifically targeting both ERα and ERβ. As the enantiomer of 17β-Estradiol, it exhibits minimal estrogenic activity, making it valuable for studies that require the modulation of estrogen receptors without significant hormonal effects. Ent-Estradiol demonstrates varying inhibitory concentrations with IC50 values of 24.9 nM, 9.59 nM, and 8.17 nM for human, rat, and mouse ERβ, respectively, and 151 nM, 246 nM, and 268 nM for ERα across the same species. This compound is instrumental in researching menopausal physiological changes and receptor-specific mechanisms.
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