EP-3945 is a selective agonist of the Mas-related G protein-coupled receptor (MRGPR), demonstrating greater efficacy compared to β-Alanine. This receptor is significantly involved in mediating inflammatory pruritus and pain responses. EP-3945 specifically activates the Gq signaling pathway, with an EC50 value of 211.6 nM, enabling its application in studies focused on pain modulation and itch sensation research.
EP-3945 is a selective agonist of the Mas-related G protein-coupled receptor (MRGPR), demonstrating greater efficacy compared to β-Alanine. This receptor is significantly involved in mediating inflammatory pruritus and pain responses. EP-3945 specifically activates the Gq signaling pathway, with an EC50 value of 211.6 nM, enabling its application in studies focused on pain modulation and itch sensation research.
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