EP009 is a selective inhibitor of JAK3, primarily targeting IL-2-mediated JAK3 tyrosine phosphorylation with an IC50 of 10-20 μM in Kit225 cells. This compound does not influence IL-3-induced JAK2 phosphorylation at concentrations up to 50 μM in BaF/3 cells. Notably, EP009 exhibits significant cytotoxicity in Kit225 cells, reducing cell viability with an LD50 of 5.0 μM, while leaving BaF/3 cells unaffected. This specificity makes EP009 a valuable reagent for research applications involving JAK3 signaling pathways.
EP009 is a selective inhibitor of JAK3, primarily targeting IL-2-mediated JAK3 tyrosine phosphorylation with an IC50 of 10-20 μM in Kit225 cells. This compound does not influence IL-3-induced JAK2 phosphorylation at concentrations up to 50 μM in BaF/3 cells. Notably, EP009 exhibits significant cytotoxicity in Kit225 cells, reducing cell viability with an LD50 of 5.0 μM, while leaving BaF/3 cells unaffected. This specificity makes EP009 a valuable reagent for research applications involving JAK3 signaling pathways.
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