EP4 receptor antagonist 1 is a highly potent and selective competitive antagonist of the prostanoid EP4 receptor, primarily utilized in cancer immunotherapy. It exhibits strong inhibition of human and mouse EP4 receptors with IC50 values of 6.1 nM and 16.2 nM, respectively, while showing minimal activity against human EP1, EP2, and EP3 receptors, with IC50s exceeding 10 μM. This specificity makes it a valuable tool for investigating the role of EP4 in various oncological processes.
EP4 receptor antagonist 1 is a highly potent and selective competitive antagonist of the prostanoid EP4 receptor, primarily utilized in cancer immunotherapy. It exhibits strong inhibition of human and mouse EP4 receptors with IC50 values of 6.1 nM and 16.2 nM, respectively, while showing minimal activity against human EP1, EP2, and EP3 receptors, with IC50s exceeding 10 μM. This specificity makes it a valuable tool for investigating the role of EP4 in various oncological processes.
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